产品
编 号：F474618
分子式：C19H29N5O2
分子量：359.47
分子式：C19H29N5O2
分子量：359.47
产品类型
规格
价格
是否有货
5mg
600
In-stock
10mg
1000
In-stock
25mg
1600
In-stock
50mg
2160
In-stock
100mg
2920
In-stock
结构图
CAS No: 83928-76-1
产品详情
生物活性：
Gepirone is a selective and affinitive 5-HT1A agonist. Gepirone binds selectively to 5-HT1A receptor binding site. Gepirone acts as an antidepressant agent can be used for anxiety and major depressive disorder research.
体内研究：
Gepirone (0-3 mg/kg，腹腔注射) 与黄体酮在 5-HT1A受体上相互作用，降低雌二醇苯甲酸酯和黄体酮处理过的雌性大鼠的脊柱前凸行为。Gepirone (10, 15 mg/kg，皮下注射，2, 7, 14 天) 激活雄性 Sprague-Dawley 大鼠突触后正常敏感的5-HT1A受体。Animal Model:Sprague-Dawley rats
Dosage:0, 0.1, 0.3, 1 and 3 mg/kg
Administration:Intraperitoneal injection (i.p.)
Result:Increases in lordotic activity at lower doses. Inhibited lordosis by the 0.3 and 1.0 mg/kg doses and further inhibition was produced by the 3.0 mg/kg dose.
Animal Model:Male Sprague-Dawley rats
Dosage:10, 15 mg/kg
Administration:Subcutaneous injection (s.c.)
Result:Decreased the number of spontaneously active 5-HT neurons and firing rate.Not modified with long-term treatment with ED50 value of 10.1±0.5 μg/kg in controls and 9.7 ±1.9 μg/kg in treated rats.
Gepirone is a selective and affinitive 5-HT1A agonist. Gepirone binds selectively to 5-HT1A receptor binding site. Gepirone acts as an antidepressant agent can be used for anxiety and major depressive disorder research.
体内研究：
Gepirone (0-3 mg/kg，腹腔注射) 与黄体酮在 5-HT1A受体上相互作用，降低雌二醇苯甲酸酯和黄体酮处理过的雌性大鼠的脊柱前凸行为。Gepirone (10, 15 mg/kg，皮下注射，2, 7, 14 天) 激活雄性 Sprague-Dawley 大鼠突触后正常敏感的5-HT1A受体。Animal Model:Sprague-Dawley rats
Dosage:0, 0.1, 0.3, 1 and 3 mg/kg
Administration:Intraperitoneal injection (i.p.)
Result:Increases in lordotic activity at lower doses. Inhibited lordosis by the 0.3 and 1.0 mg/kg doses and further inhibition was produced by the 3.0 mg/kg dose.
Animal Model:Male Sprague-Dawley rats
Dosage:10, 15 mg/kg
Administration:Subcutaneous injection (s.c.)
Result:Decreased the number of spontaneously active 5-HT neurons and firing rate.Not modified with long-term treatment with ED50 value of 10.1±0.5 μg/kg in controls and 9.7 ±1.9 μg/kg in treated rats.
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