产品
编 号：F474462
分子式：C16H25NO2
分子量：263.38
分子式：C16H25NO2
分子量：263.38
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
2000
In-stock
10mg
3200
In-stock
结构图
CAS No: 83883-10-7
产品详情
生物活性：
Hydroxy-α-sanshool is a transient receptor potential ankyrin 1 (TRPA1) and TRP vanilloid 1 (TRPV1) agonist with EC50s of 69 and 1.1 μM, respectively. Hydroxy-α-sanshool can be used for pain research.
体内研究：
Hydroxy-α-sanshool (intradermal injection; 4 mg per mouse; once) shows paw-licking response in wild-type and TRPV1-deficient mice.Hydroxy-α-sanshool (1 mM) ismarkedly aversive to WT mice, but in TRPV1 KO mice, the aversion is almost entirely eliminated (P<0.001).Animal Model:Wild-type and TRPV1-deficient mice
Dosage:4 mg per mouse
Administration:Intradermal injection; 4 mg per mouse; once
Result:Reduced paw-licking response in TRPV1-deficient mice (160 times, P < 0.05).Showed paw-licking response in wild-type mice (mean 284.8 times) in 20 min.
体外研究：
Hydroxy-α-sanshool (0-10 mM; 20 s) induces inward currents in cultured DRG neuron.Hydroxy-α-sanshool (1 mM; 0-1 min) increases intracellular Ca2+ in cultured DRG neuron.
Hydroxy-α-sanshool is a transient receptor potential ankyrin 1 (TRPA1) and TRP vanilloid 1 (TRPV1) agonist with EC50s of 69 and 1.1 μM, respectively. Hydroxy-α-sanshool can be used for pain research.
体内研究：
Hydroxy-α-sanshool (intradermal injection; 4 mg per mouse; once) shows paw-licking response in wild-type and TRPV1-deficient mice.Hydroxy-α-sanshool (1 mM) ismarkedly aversive to WT mice, but in TRPV1 KO mice, the aversion is almost entirely eliminated (P<0.001).Animal Model:Wild-type and TRPV1-deficient mice
Dosage:4 mg per mouse
Administration:Intradermal injection; 4 mg per mouse; once
Result:Reduced paw-licking response in TRPV1-deficient mice (160 times, P < 0.05).Showed paw-licking response in wild-type mice (mean 284.8 times) in 20 min.
体外研究：
Hydroxy-α-sanshool (0-10 mM; 20 s) induces inward currents in cultured DRG neuron.Hydroxy-α-sanshool (1 mM; 0-1 min) increases intracellular Ca2+ in cultured DRG neuron.
产品资料
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