产品
编 号：F474442
分子式：C21H25ClN2O3
分子量：388.89
分子式：C21H25ClN2O3
分子量：388.89
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
50mg
询价
询价
100mg
询价
询价
结构图
CAS No: 83881-51-0
产品详情
生物活性：
Cetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response.
体内研究：
Cetirizine (20 mg/kg, mice, orally) exerts its anti-inflammatory effects by inhibiting MIF as well as IL-8 production in mice immunized and challenged with ragweed pollen.Animal Model:Male 8-week-old BALB/c mice (25-30 g) immunized and challenged with ragweed pollen.
Dosage:2 or 20 mg/kg.
Administration:Orally, diluted in sterile water on days 18, 19, and 20.
Result:The neutrophilia at 8 h and eosinophilia at 24 h induced by ragweed pollen extract per oswere significantly reduced in the mice treated with 20 mg/kg. The dosage with 2 mg/kg had no effect.
体外研究：
Cetirizine (>5 μM) at higher concentrations can reduce the release of GM-CSF and IL-8 from A549 cells stimulated with IL-1β. Cetirizine exerts anti-inflammatory effects beyond histamine H1-receptor antagonist.
Cetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response.
体内研究：
Cetirizine (20 mg/kg, mice, orally) exerts its anti-inflammatory effects by inhibiting MIF as well as IL-8 production in mice immunized and challenged with ragweed pollen.Animal Model:Male 8-week-old BALB/c mice (25-30 g) immunized and challenged with ragweed pollen.
Dosage:2 or 20 mg/kg.
Administration:Orally, diluted in sterile water on days 18, 19, and 20.
Result:The neutrophilia at 8 h and eosinophilia at 24 h induced by ragweed pollen extract per oswere significantly reduced in the mice treated with 20 mg/kg. The dosage with 2 mg/kg had no effect.
体外研究：
Cetirizine (>5 μM) at higher concentrations can reduce the release of GM-CSF and IL-8 from A549 cells stimulated with IL-1β. Cetirizine exerts anti-inflammatory effects beyond histamine H1-receptor antagonist.
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