产品
编 号：F473879
分子式：C10H6O3
分子量：174.15
分子式：C10H6O3
分子量：174.15
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
500mg
440
In-stock
结构图
CAS No: 83-72-7
产品详情
生物活性：
Lawsone is an orally active naphthoquinone dye that can be isolated from the leaves of Lawsonia inermis. Lawsone can induce apoptosis. Lawsone has antibacterial, antitumor and antioxidant activities. Lawsone can be used in anti-tumor drug research.
体内研究：
Lawsone (62.5, 125, 250, 500, 750 μmol/kg/day, 口服) 在大鼠中可诱导与红细胞氧化损伤相关的溶血反应。Lawsone (200 mg/mL, 口服, 持续 8 周) 对大鼠结肠癌有明显的抑制作用。Animal Model:Female rat model (10-11- week-old)
Dosage:62.5, 125, 250, 500, 750 μmol/kg/day
Administration:p.o.
Result:Increased the levels of ALT、AST、GLDH、LDH、HBDH、urea and creatinine at a dose of 500 or 750 μmol/kg/day.
Animal Model:Rat model of colon cancer
Dosage: 200 mg/mL
Administration:p.o.
Result:Reduced the tumor diameters and decreased multiplicity of these adenomas.Decreased the PCNA staining index
体外研究：
Lawsone (125, 250, 500 μM, 18 h) 剂量依赖性的抑制大肠杆菌的生长。Lawsone (0.5, 1, 1.5, 2 mg/mL, 48 h) 在人 DLD-1 细胞中通过降低 NF-κB活性导致细胞周期蛋白 B1 和 cdk1 的表达水平受到抑制而抑制细胞增殖。Lawsone (10, 20, 40, 80, 160 mg/mL, 24 h) 在 SKOV-3 卵巢癌细胞中具有抗增殖作用，通过抑制 Bcl-2 诱导细胞凋亡。
Lawsone is an orally active naphthoquinone dye that can be isolated from the leaves of Lawsonia inermis. Lawsone can induce apoptosis. Lawsone has antibacterial, antitumor and antioxidant activities. Lawsone can be used in anti-tumor drug research.
体内研究：
Lawsone (62.5, 125, 250, 500, 750 μmol/kg/day, 口服) 在大鼠中可诱导与红细胞氧化损伤相关的溶血反应。Lawsone (200 mg/mL, 口服, 持续 8 周) 对大鼠结肠癌有明显的抑制作用。Animal Model:Female rat model (10-11- week-old)
Dosage:62.5, 125, 250, 500, 750 μmol/kg/day
Administration:p.o.
Result:Increased the levels of ALT、AST、GLDH、LDH、HBDH、urea and creatinine at a dose of 500 or 750 μmol/kg/day.
Animal Model:Rat model of colon cancer
Dosage: 200 mg/mL
Administration:p.o.
Result:Reduced the tumor diameters and decreased multiplicity of these adenomas.Decreased the PCNA staining index
体外研究：
Lawsone (125, 250, 500 μM, 18 h) 剂量依赖性的抑制大肠杆菌的生长。Lawsone (0.5, 1, 1.5, 2 mg/mL, 48 h) 在人 DLD-1 细胞中通过降低 NF-κB活性导致细胞周期蛋白 B1 和 cdk1 的表达水平受到抑制而抑制细胞增殖。Lawsone (10, 20, 40, 80, 160 mg/mL, 24 h) 在 SKOV-3 卵巢癌细胞中具有抗增殖作用，通过抑制 Bcl-2 诱导细胞凋亡。
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