产品
编 号：F473616
分子式：C22H30N2O5S2
分子量：466.61
分子式：C22H30N2O5S2
分子量：466.61
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CAS No: 83647-97-6
产品详情
生物活性：
Spirapril is a potent and cross the blood-brain barrier angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Spirapril competitively binds to ACE and prevents the conversion of angiotensin I to angiotensin II. Spirapril is an orally active proagent of Spiraprilat and can be used for the research of hypertension, congestive heart failure.
体内研究：
Spirapril (feeding needle; 10 mg/kg; 3 weeks) decreases alcohol intake in TGM123 mice and dose not reduce the alcohol consumption in TLM mice.Spirapril shows a 40.2% reduction in ACE activity in brain membrane from treated-mice.Spirapril can crosses the blood-brain barrier and suppresses the transgene effect in the experiments.Spirapril prevents left ventricular hypertrophy, decreases myocardial damage and promotes angiogenesis in spontaneously hypertensive rats.
Spirapril is a potent and cross the blood-brain barrier angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Spirapril competitively binds to ACE and prevents the conversion of angiotensin I to angiotensin II. Spirapril is an orally active proagent of Spiraprilat and can be used for the research of hypertension, congestive heart failure.
体内研究：
Spirapril (feeding needle; 10 mg/kg; 3 weeks) decreases alcohol intake in TGM123 mice and dose not reduce the alcohol consumption in TLM mice.Spirapril shows a 40.2% reduction in ACE activity in brain membrane from treated-mice.Spirapril can crosses the blood-brain barrier and suppresses the transgene effect in the experiments.Spirapril prevents left ventricular hypertrophy, decreases myocardial damage and promotes angiogenesis in spontaneously hypertensive rats.
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