产品
编 号：F471637
分子式：C18H22N2
分子量：266.38
分子式：C18H22N2
分子量：266.38
产品类型
规格
价格
是否有货
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
结构图
CAS No: 82-92-8
产品详情
生物活性：
Cyclizine, a piperazine-derivative, is a potent and selective histamine H1 receptor antagonist. Cyclizine can be used for the research of nausea, vomiting, and dizziness.
体内研究：
Cyclizine (1, 10 mg/kg) enhances locomotor activity of mice in a dose-dependent manner.Animal Model:Naive male CDI mice (Charles River) weighing 25-30 g
Dosage:1, 10 mg/kg
Administration:s.c.; locomotor activity (crossings) measured every 15 min for 2 hr.
Result:Enhanced locomotor activity in a dose-dependent manner.
体外研究：
Cyclizine (100 μM) significantly inhibits nitrite accumulation and iNOS protein levels in the LPS-stimulated in RAW 264.7 cells supernatants.Cyclizine inhibits anti-IgE-induced histamine release from isolated human lung fragments, with an IC50 of 5.42 μM.
Cyclizine, a piperazine-derivative, is a potent and selective histamine H1 receptor antagonist. Cyclizine can be used for the research of nausea, vomiting, and dizziness.
体内研究：
Cyclizine (1, 10 mg/kg) enhances locomotor activity of mice in a dose-dependent manner.Animal Model:Naive male CDI mice (Charles River) weighing 25-30 g
Dosage:1, 10 mg/kg
Administration:s.c.; locomotor activity (crossings) measured every 15 min for 2 hr.
Result:Enhanced locomotor activity in a dose-dependent manner.
体外研究：
Cyclizine (100 μM) significantly inhibits nitrite accumulation and iNOS protein levels in the LPS-stimulated in RAW 264.7 cells supernatants.Cyclizine inhibits anti-IgE-induced histamine release from isolated human lung fragments, with an IC50 of 5.42 μM.
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