产品
编 号：F471448
分子式：C19H32N2O5
分子量：368.47
分子式：C19H32N2O5
分子量：368.47
产品类型
规格
价格
是否有货
100mg
询价
询价
结构图
CAS No: 82834-16-0
产品详情
生物活性：
Perindopril erbumine is an angiotensin-converting enzyme inhibitor. Perindopril erbumine modulates NFκB and STAT3 signaling and inhibits glial activation and neuroinflammation. Perindopril erbumine can be used for the research of Chronic Kidney Disease and high blood pressure.
体内研究：
Perindopril erbumine (0.1 mg/kg, Oral gavage, once a day for five consecutive days) prevents LPS-induced neuroinflammation in rats.Perindopril erbumine (0.42 mg/kg, Oral, once a day for 4 weeks) with Huangqi-Danshen decoction (HDD) (4.7 g/kg, Oral, once a day for 4 weeks) attenuates adenine-induced Chronic kidney disease (CKD) in rats.Perindopril erbumine (0.4-1.5 mg/kg, Oral, once a day for 4-24 weeks) has a persistent effect on blood pressure in spontaneously hypertensive rats (SHR).Animal Model:LPS-induced neuroinflammation rat model
Dosage:0.1 mg/kg
Administration:Oral gavage (p.o.)
Result:Abolished the LPS-induced astroglial and microglial activation.Attenuated LPS-induced TNF-α production.Prevented LPS-induced nuclear translocation of NF-кB.Prevented the AT1R up-regulation and the LPS-induced decrease in the expression of PP2A.
Animal Model:Adenine-induced chronic kidney disease rats
Dosage:0.42 mg/kg
Administration:Oral
Result:Obviously reduced serum creatinine (Scr) and blood urea nitrogen (BUN) levels.Displayed a marked reduction of tubulointerstitial fibrosis.Exhibited more inhibitory effect on Col-IV expression and a exceed effect of raising OPA-1 expression.Significantly increased Sirtuin3 expression.Prevented mitochondrial fragmentation.
体外研究：
Perindopril erbumine (1 μM, 24 h) 改善 LPS (HY-D1056) 诱导的大鼠星形细胞瘤细胞系 (C6) 和小鼠小胶质细胞系(BV2) 中 AT2R 表达的减少和胶质增。Perindopril erbumine (1 μM, 24 h) 抑制LPS (HY-D1056) 诱导的大鼠星形细胞瘤细胞系 (C6) 和小鼠小胶质细胞系(BV2)中 IκBα 降解，NF кB 核转位和 STAT3 活化。Perindopril erbumine (1 μM, 24 h) 改善LPS (HY-D1056) 诱导的大鼠星形细胞瘤细胞系 (C6) 和小鼠小胶质细胞系(BV2) 中炎症因子释放失衡，抑制活性氧生成和亚硝酸盐释放。
Perindopril erbumine is an angiotensin-converting enzyme inhibitor. Perindopril erbumine modulates NFκB and STAT3 signaling and inhibits glial activation and neuroinflammation. Perindopril erbumine can be used for the research of Chronic Kidney Disease and high blood pressure.
体内研究：
Perindopril erbumine (0.1 mg/kg, Oral gavage, once a day for five consecutive days) prevents LPS-induced neuroinflammation in rats.Perindopril erbumine (0.42 mg/kg, Oral, once a day for 4 weeks) with Huangqi-Danshen decoction (HDD) (4.7 g/kg, Oral, once a day for 4 weeks) attenuates adenine-induced Chronic kidney disease (CKD) in rats.Perindopril erbumine (0.4-1.5 mg/kg, Oral, once a day for 4-24 weeks) has a persistent effect on blood pressure in spontaneously hypertensive rats (SHR).Animal Model:LPS-induced neuroinflammation rat model
Dosage:0.1 mg/kg
Administration:Oral gavage (p.o.)
Result:Abolished the LPS-induced astroglial and microglial activation.Attenuated LPS-induced TNF-α production.Prevented LPS-induced nuclear translocation of NF-кB.Prevented the AT1R up-regulation and the LPS-induced decrease in the expression of PP2A.
Animal Model:Adenine-induced chronic kidney disease rats
Dosage:0.42 mg/kg
Administration:Oral
Result:Obviously reduced serum creatinine (Scr) and blood urea nitrogen (BUN) levels.Displayed a marked reduction of tubulointerstitial fibrosis.Exhibited more inhibitory effect on Col-IV expression and a exceed effect of raising OPA-1 expression.Significantly increased Sirtuin3 expression.Prevented mitochondrial fragmentation.
体外研究：
Perindopril erbumine (1 μM, 24 h) 改善 LPS (HY-D1056) 诱导的大鼠星形细胞瘤细胞系 (C6) 和小鼠小胶质细胞系(BV2) 中 AT2R 表达的减少和胶质增。Perindopril erbumine (1 μM, 24 h) 抑制LPS (HY-D1056) 诱导的大鼠星形细胞瘤细胞系 (C6) 和小鼠小胶质细胞系(BV2)中 IκBα 降解，NF кB 核转位和 STAT3 活化。Perindopril erbumine (1 μM, 24 h) 改善LPS (HY-D1056) 诱导的大鼠星形细胞瘤细胞系 (C6) 和小鼠小胶质细胞系(BV2) 中炎症因子释放失衡，抑制活性氧生成和亚硝酸盐释放。
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