产品
编 号：F471013
分子式：C16H12N2O3S
分子量：312.34
分子式：C16H12N2O3S
分子量：312.34
产品类型
规格
价格
是否有货
1mg
询价
询价
结构图
CAS No: 827001-82-1
产品详情
生物活性：
5J-4 is a potent CRAC inhibitor. 5J-4 decreases the numbers of infiltrated mononuclear cell into the CNS, and significantly decreases the population of infiltrated CD4+ population. 5J-4 reduces the symptoms and delayed the onset of EAE (experimental autoimmune encephalomyelitis) in mouse model of inflammation.
体内研究：
5J-4 reduces the production of IL-17 and decreases the expression of RORα and RORγt.5J-4 (2 mg/kg; i.p.; every alternate day for 30 days) reduces the symptoms and delayed the onset of EAE.Animal Model:C57BL/6 mice (MOG35-55 peptide-immunized mice)
Dosage:2 m/kg
Administration:I.p., every alternate day for 30 days
Result:Dramatically reduced the symptoms and delayed the onset of EAE and decreased the numbers of infiltrated mononuclear cell into the CNS, and significantly decreased the population of infiltrated CD4+ population.
5J-4 is a potent CRAC inhibitor. 5J-4 decreases the numbers of infiltrated mononuclear cell into the CNS, and significantly decreases the population of infiltrated CD4+ population. 5J-4 reduces the symptoms and delayed the onset of EAE (experimental autoimmune encephalomyelitis) in mouse model of inflammation.
体内研究：
5J-4 reduces the production of IL-17 and decreases the expression of RORα and RORγt.5J-4 (2 mg/kg; i.p.; every alternate day for 30 days) reduces the symptoms and delayed the onset of EAE.Animal Model:C57BL/6 mice (MOG35-55 peptide-immunized mice)
Dosage:2 m/kg
Administration:I.p., every alternate day for 30 days
Result:Dramatically reduced the symptoms and delayed the onset of EAE and decreased the numbers of infiltrated mononuclear cell into the CNS, and significantly decreased the population of infiltrated CD4+ population.
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