产品
编 号：F470894
分子式：C11H22ClN
分子量：203.75
分子式：C11H22ClN
分子量：203.75
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
224
In-stock
5mg
560
In-stock
10mg
920
In-stock
25mg
2000
In-stock
50mg
3200
In-stock
结构图
CAS No: 826-39-1
产品详情
生物活性：
Mecamylamine hydrochloride is an orally active, nonselective, noncompetitive nAChR antagonist. Mecamylamine hydrochloride is also a ganglionic blocker. Mecamylamine hydrochloride can across the blood-brain barrier. Mecamylamine hydrochloride can be used in the research of neuropsychiatric disorders, hypertension, antidepressant area.
体内研究：
Mecamylamine hydrochloride (皮下泵，50 mg/kg/天，2 天) 抑制 CNV 小鼠模型中的脉络膜新生血管 (CNV)。Mecamylamine hydrochloride (腹膜内注射，0.5-1 mg/kg) 在依赖于 β2 和 α7 亚基的 C57BL/6J 小鼠的 TST (悬尾试验) 和 FST (强迫游泳试验) 中均具有抗抑郁样作用。Animal Model:Choroidal neovascularization (CNV) mice model
Dosage:50 mg/kg/day, 2 days
Administration:Subcutaneous pumps implanted beneath the skin of the back, 200 μL and mean pumping rate of 0.5 μL/h.
Result:Suppressed the development of CNV at Bruch’s membrane rupture sites in the absence of nicotine.
Animal Model:C57BL/6J mice
Dosage:0.5-1 mg/kg
Administration:Intraperitoneal injection
Result:Had no effect in β2 knockout mice and α7 knockout mice, but decreased immobility time in wildtype littermates in the FST.
体外研究：
Mecamylamine hydrochloride（0.5-9 μM，沐浴给药）增加已识别的 5-HT DRN（中缝背核）神经元的放电频率。Mecamylamine hydrochloride（0.5-9 μM，沐浴给药）增加谷氨酸能并降低 5-HT DRN 神经元的 GABA 能输入。Mecamylamine hydrochloride（1 mM，5 分钟）阻断兔主动脉螺旋切条中的组胺受体和组胺诱导的收缩。Mecamylamine hydrochloride (10 μM，48 h) 减弱尼古丁的神经保护作用。Mecamylamine hydrochloride（1-100 nM，30 分钟）以剂量依赖性方式减弱 HDMVEC 中的内皮管形成。
Mecamylamine hydrochloride is an orally active, nonselective, noncompetitive nAChR antagonist. Mecamylamine hydrochloride is also a ganglionic blocker. Mecamylamine hydrochloride can across the blood-brain barrier. Mecamylamine hydrochloride can be used in the research of neuropsychiatric disorders, hypertension, antidepressant area.
体内研究：
Mecamylamine hydrochloride (皮下泵，50 mg/kg/天，2 天) 抑制 CNV 小鼠模型中的脉络膜新生血管 (CNV)。Mecamylamine hydrochloride (腹膜内注射，0.5-1 mg/kg) 在依赖于 β2 和 α7 亚基的 C57BL/6J 小鼠的 TST (悬尾试验) 和 FST (强迫游泳试验) 中均具有抗抑郁样作用。Animal Model:Choroidal neovascularization (CNV) mice model
Dosage:50 mg/kg/day, 2 days
Administration:Subcutaneous pumps implanted beneath the skin of the back, 200 μL and mean pumping rate of 0.5 μL/h.
Result:Suppressed the development of CNV at Bruch’s membrane rupture sites in the absence of nicotine.
Animal Model:C57BL/6J mice
Dosage:0.5-1 mg/kg
Administration:Intraperitoneal injection
Result:Had no effect in β2 knockout mice and α7 knockout mice, but decreased immobility time in wildtype littermates in the FST.
体外研究：
Mecamylamine hydrochloride（0.5-9 μM，沐浴给药）增加已识别的 5-HT DRN（中缝背核）神经元的放电频率。Mecamylamine hydrochloride（0.5-9 μM，沐浴给药）增加谷氨酸能并降低 5-HT DRN 神经元的 GABA 能输入。Mecamylamine hydrochloride（1 mM，5 分钟）阻断兔主动脉螺旋切条中的组胺受体和组胺诱导的收缩。Mecamylamine hydrochloride (10 μM，48 h) 减弱尼古丁的神经保护作用。Mecamylamine hydrochloride（1-100 nM，30 分钟）以剂量依赖性方式减弱 HDMVEC 中的内皮管形成。
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