产品
编 号:F470891
分子式:C9H17NO
分子量:155.24
产品类型
结构图
CAS No: 826-36-8
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生物活性:
Triacetonamine (2,2,6,6-Tetramethyl-4-piperidone) is used as an intermediate for the synthesis of pharmaceutical products, pesticides and photostabilizers for polymers. Triacetonamine has oral activity and can induce acute liver failure (ALF) in rats.
体内研究:
Triacetonamine (200 mg、300 mg、400 mg/Kg/天;灌胃;2 天) 显示在剂量为 300 mg/Kg/天和 400 mg/Kg/天会出现典型的 ALF 肝肠病理学,而 400 mg/Kg/day组的死亡率较高。Animal Model:Rats (half male and female, 6-8 weeks old, 200?±?10 g)
Dosage:200 mg, 300 mg, 400 mg/Kg
Administration:Gavage; daily; 2 days
Result:Showed typical hepatoenteropathology of ALF with 300 mg/Kg/day and 400 mg/Kg/day, while the group of 400 mg/Kg/day had higher mortality.