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编 号：F055477
分子式：C8H15N2O5P
分子量：250.19
分子式：C8H15N2O5P
分子量：250.19
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CAS No: 117414-74-1
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生物活性：
Midafotel (SDZ-EAA 494) is a potent and comprtitive NMDA antagonist with an ED50 value of 39 nM. Midafotel causes intense stereotyped behaviors. Midafotel shows neuroprotective effects.
体内研究：
Midafotel (15 mg/kg；腹腔注射) 在大鼠中引起强烈的刻板行为。Midafotel (1.5、4.5、15 mg/kg；静脉注射；在 MCA 阻塞前 15 分钟开始 (随后以 1、3 或 10 mg/kg/h 持续输注)) 产生剂量依赖性体积减少梗死; 4.5 mg/kg剂量对大鼠局灶性脑缺血最有效。Animal Model:Adult female Wistar rats
Dosage:15 mg/kg
Administration:I.p.
Result:Induced the typical PCP-like behavioral syndrome with ataxia, hyperlocomotion and stereotyped behaviors, i.e., head weaving, stereotyped sniffing, face washing and grooming, significantly increased extracellular levels of HVA and 5-HIAA in the striatum.
Midafotel (SDZ-EAA 494) is a potent and comprtitive NMDA antagonist with an ED50 value of 39 nM. Midafotel causes intense stereotyped behaviors. Midafotel shows neuroprotective effects.
体内研究：
Midafotel (15 mg/kg；腹腔注射) 在大鼠中引起强烈的刻板行为。Midafotel (1.5、4.5、15 mg/kg；静脉注射；在 MCA 阻塞前 15 分钟开始 (随后以 1、3 或 10 mg/kg/h 持续输注)) 产生剂量依赖性体积减少梗死; 4.5 mg/kg剂量对大鼠局灶性脑缺血最有效。Animal Model:Adult female Wistar rats
Dosage:15 mg/kg
Administration:I.p.
Result:Induced the typical PCP-like behavioral syndrome with ataxia, hyperlocomotion and stereotyped behaviors, i.e., head weaving, stereotyped sniffing, face washing and grooming, significantly increased extracellular levels of HVA and 5-HIAA in the striatum.
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