产品
编 号：F470227
分子式：C26H29NO2
分子量：387.51
分子式：C26H29NO2
分子量：387.51
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
询价
询价
5mg
询价
询价
结构图
CAS No: 82413-20-5
产品详情
生物活性：
Droloxifene, a Tamoxifen derivative, is an orally active and selective estrogen receptor modulator. Droloxifene shows antiestrogenic and anti-implantation effects. Droloxifene induces p53 expression and apoptosis in MCF-7 cells. Droloxifene prevents bone loss in ovariectomized rats .
体内研究：
Droloxifene (5-20 mg/kg; p.o.; daily for 4 weeks) increases BMD of DFM at 10mg/kg, and completely prevents the decrease of BMC and BMD of DFM induced by ovariectomized (OVX) at 20 mg/kg/day.Animal Model:5-month-old sham-operate rats
Dosage:5, 10, 20 mg/kg
Administration:Oral; daily for 4 weeks
Result:BMD of DFM increased significantly at 10mg/kg; completely prevented the decrease of BMC and BMD of DFM induced by OVX at 20 mg/kg/day.
体外研究：
Droloxifene (10 nM; 16-18 hours) induces apoptosis in MCF-7 cells.
Droloxifene, a Tamoxifen derivative, is an orally active and selective estrogen receptor modulator. Droloxifene shows antiestrogenic and anti-implantation effects. Droloxifene induces p53 expression and apoptosis in MCF-7 cells. Droloxifene prevents bone loss in ovariectomized rats .
体内研究：
Droloxifene (5-20 mg/kg; p.o.; daily for 4 weeks) increases BMD of DFM at 10mg/kg, and completely prevents the decrease of BMC and BMD of DFM induced by ovariectomized (OVX) at 20 mg/kg/day.Animal Model:5-month-old sham-operate rats
Dosage:5, 10, 20 mg/kg
Administration:Oral; daily for 4 weeks
Result:BMD of DFM increased significantly at 10mg/kg; completely prevented the decrease of BMC and BMD of DFM induced by OVX at 20 mg/kg/day.
体外研究：
Droloxifene (10 nM; 16-18 hours) induces apoptosis in MCF-7 cells.
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