产品
编 号：F469878
分子式：C17H22ClNO
分子量：291.82
分子式：C17H22ClNO
分子量：291.82
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
100mg
608
In-stock
结构图
CAS No: 82248-59-7
产品详情
生物活性：
Atomoxetine (Tomoxetine) hydrochloride is a selective noradrenaline reuptake inhibitor with Ki values of 5 nM, 77 nM and 1451 nM for norepinephrine (NE), serotonin (5-HT) and dopamine (DA) transporters, respectively. Atomoxetine hydrochloride is a potent Na+ channels (VGSCs) blocker. Atomoxetine hydrochloride can be used for attention-deficit hyperactivity disorder (ADHD) research.
体内研究：
Atomoxetine hydrochloride（0.3-3 mg/kg；腹腔注射；0-4 小时；雄性 Sprague-Dawley 大鼠）可使细胞外去甲肾上腺素和多巴胺增加 3 倍，并增加大鼠前额皮质中 Fos 的表达 .Atomoxetine hydrochloride（0.1-5 mg/kg；腹腔注射和口服；持续 14 天；自发性高血压大鼠）可以改善大鼠与 ADHD 相关的行为。Animal Model:Male Sprague-Dawley rats
Dosage:0.3, 1 and 3 mg/kg
Administration:Intraperitoneal injection; for 4 hours
Result:Increased the number of cells expressing Fos-like immunoreactivity in PFC 3.7-fold and increased extracellular norepinephrine and dopamine by 3-fold.
Animal Model:Spontaneously hypertensive rat (SHR)
Dosage:0.1, 0.3, 1.25 and 5.0 mg/kg
Administration:Intraperitoneal injection and oral administration; for 14 days
Result:Had non-impact on the measurement of motor activity.
体外研究：
Atomoxetine (Tomoxetine) hydrochloride（1-100 μM；0.5-20 秒；tsA201 细胞）与人心肌钠通道 (hNav1.5) 相互作用，呈状态和剂量依赖性 .
Atomoxetine (Tomoxetine) hydrochloride is a selective noradrenaline reuptake inhibitor with Ki values of 5 nM, 77 nM and 1451 nM for norepinephrine (NE), serotonin (5-HT) and dopamine (DA) transporters, respectively. Atomoxetine hydrochloride is a potent Na+ channels (VGSCs) blocker. Atomoxetine hydrochloride can be used for attention-deficit hyperactivity disorder (ADHD) research.
体内研究：
Atomoxetine hydrochloride（0.3-3 mg/kg；腹腔注射；0-4 小时；雄性 Sprague-Dawley 大鼠）可使细胞外去甲肾上腺素和多巴胺增加 3 倍，并增加大鼠前额皮质中 Fos 的表达 .Atomoxetine hydrochloride（0.1-5 mg/kg；腹腔注射和口服；持续 14 天；自发性高血压大鼠）可以改善大鼠与 ADHD 相关的行为。Animal Model:Male Sprague-Dawley rats
Dosage:0.3, 1 and 3 mg/kg
Administration:Intraperitoneal injection; for 4 hours
Result:Increased the number of cells expressing Fos-like immunoreactivity in PFC 3.7-fold and increased extracellular norepinephrine and dopamine by 3-fold.
Animal Model:Spontaneously hypertensive rat (SHR)
Dosage:0.1, 0.3, 1.25 and 5.0 mg/kg
Administration:Intraperitoneal injection and oral administration; for 14 days
Result:Had non-impact on the measurement of motor activity.
体外研究：
Atomoxetine (Tomoxetine) hydrochloride（1-100 μM；0.5-20 秒；tsA201 细胞）与人心肌钠通道 (hNav1.5) 相互作用，呈状态和剂量依赖性 .
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