产品
编 号：F469677
分子式：C17H15F6N5O
分子量：419.32
分子式：C17H15F6N5O
分子量：419.32
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
50mg
询价
询价
100mg
询价
询价
结构图
CAS No: 821768-06-3
产品详情
生物活性：
JNJ-17203212 is a selective, potent and competitive TRPV1 antagonist. JNJ-17203212 is developed for researching pain management, such as migraine.
体内研究：
JNJ-17203212 (0.3 mg/kg; i.v.) dose-dependently reduces inflammatory soup (IS)-induced the immediate early gene c-fos expression.JNJ-17203212 completely blocks capsaicin-induced CGRP (the neurotransmitter calcitonin gene-related peptide) release in a dose-dependent manner.Animal Model:Male Sprague-Dawley rats (260-300 g)
Dosage:0.3 mg/kg
Administration:Intravenous injection
Result:Had a dose-dependent effect on the elevated c-fos expression that occurred after intracisternal injection of IS.
体外研究：
JNJ-17203212 (0.5 μM) potently inhibits imperatorin-induced TRPV1 activation (Ca2+ increases) in TRPV1-expressing HEK cells.
JNJ-17203212 is a selective, potent and competitive TRPV1 antagonist. JNJ-17203212 is developed for researching pain management, such as migraine.
体内研究：
JNJ-17203212 (0.3 mg/kg; i.v.) dose-dependently reduces inflammatory soup (IS)-induced the immediate early gene c-fos expression.JNJ-17203212 completely blocks capsaicin-induced CGRP (the neurotransmitter calcitonin gene-related peptide) release in a dose-dependent manner.Animal Model:Male Sprague-Dawley rats (260-300 g)
Dosage:0.3 mg/kg
Administration:Intravenous injection
Result:Had a dose-dependent effect on the elevated c-fos expression that occurred after intracisternal injection of IS.
体外研究：
JNJ-17203212 (0.5 μM) potently inhibits imperatorin-induced TRPV1 activation (Ca2+ increases) in TRPV1-expressing HEK cells.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备