产品
编 号：F468411
分子式：C38H40N10
分子量：636.79
分子式：C38H40N10
分子量：636.79
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
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10mg
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25mg
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50mg
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100mg
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结构图
CAS No: 81624-55-7
产品详情
生物活性：
NSC348884 is a nucleophosmin (NPM) inhibitor, it disrupts oligomer formation and induces apoptosis, inhibits cell proliferation with IC50s of 1.7-4.0 μM in distinct cancer cell lines. NSC348884 can be used for the research of cancer.
体内研究：
NSC348884 (50 μg; i.p. once) reduces tumor growth.Animal Model:C57Bl/6J mice with MOSEC/Luc cells injection
Dosage:50 μg
Administration:Intraperitoneal injection; 50 μg once
Result:Reduced tumorigenesis, but not completely inhibited.
体外研究：
NSC348884 (0-6 μM; 24 h) binds with NPM and disrupts NPM oligomer formation.NSC348884 (0.01-100 μM; 4 d) shows cytotoxicity to cancer cells.NSC348884 (1 μM; 4 d) shows cytotoxicity to mantle cell lymphoma with 0.1 nM doxorubicin.NSC348884 (1-5 μM; 24 h) induces cell apoptosis.NSC348884 (0-5 μM; 0-24 h) upregulates the concentration of p53.
NSC348884 is a nucleophosmin (NPM) inhibitor, it disrupts oligomer formation and induces apoptosis, inhibits cell proliferation with IC50s of 1.7-4.0 μM in distinct cancer cell lines. NSC348884 can be used for the research of cancer.
体内研究：
NSC348884 (50 μg; i.p. once) reduces tumor growth.Animal Model:C57Bl/6J mice with MOSEC/Luc cells injection
Dosage:50 μg
Administration:Intraperitoneal injection; 50 μg once
Result:Reduced tumorigenesis, but not completely inhibited.
体外研究：
NSC348884 (0-6 μM; 24 h) binds with NPM and disrupts NPM oligomer formation.NSC348884 (0.01-100 μM; 4 d) shows cytotoxicity to cancer cells.NSC348884 (1 μM; 4 d) shows cytotoxicity to mantle cell lymphoma with 0.1 nM doxorubicin.NSC348884 (1-5 μM; 24 h) induces cell apoptosis.NSC348884 (0-5 μM; 0-24 h) upregulates the concentration of p53.
产品资料
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