产品
编 号：F468039
分子式：C20H30O2
分子量：302.45
分子式：C20H30O2
分子量：302.45
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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2mg
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5mg
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10mg
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50mg
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100mg
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结构图
CAS No: 81485-25-8
产品详情
生物活性：
Peretinoin is an oral acyclic retinoid with a vitamin A-like structure that targets retinoid nuclear receptors such as retinoid X receptor (RXR) and retinoic acid receptor (RAR). Peretinoin reduces the mRNA level of sphingosine kinase 1 (SPHK1) in vitro by downregulating a transcription factor, Sp1. Peretinoin prevents the progression of non-alcoholic steatohepatitis (NASH) and the development of hepatocellular carcinoma (HCC) through activating the autophagy pathway by increased Atg16L1 expression. Peretinoin inhibits HCV RNA amplification and virus release by altering lipid metabolism with a EC50 of 9 μM.
体外研究：
Peretinoin (10-40 μM；12-72小时) 在 24 小时处理后表现出抑制的 SPHK1 表达，即使在 10 μM 时，并且在 72 小时 peretinoin 处理后更显著。Peretinoin (5 μM；24 小时) 上调小鼠原代肝细胞 LC3B-II 的表达并增加自噬通量。
Peretinoin is an oral acyclic retinoid with a vitamin A-like structure that targets retinoid nuclear receptors such as retinoid X receptor (RXR) and retinoic acid receptor (RAR). Peretinoin reduces the mRNA level of sphingosine kinase 1 (SPHK1) in vitro by downregulating a transcription factor, Sp1. Peretinoin prevents the progression of non-alcoholic steatohepatitis (NASH) and the development of hepatocellular carcinoma (HCC) through activating the autophagy pathway by increased Atg16L1 expression. Peretinoin inhibits HCV RNA amplification and virus release by altering lipid metabolism with a EC50 of 9 μM.
体外研究：
Peretinoin (10-40 μM；12-72小时) 在 24 小时处理后表现出抑制的 SPHK1 表达，即使在 10 μM 时，并且在 72 小时 peretinoin 处理后更显著。Peretinoin (5 μM；24 小时) 上调小鼠原代肝细胞 LC3B-II 的表达并增加自噬通量。
产品资料
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