产品
编 号:F467882
分子式:C19H27N5O4
分子量:389.45
产品类型
结构图
CAS No: 81403-80-7
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生物活性:
Alfuzosin (SL 77499-10) is an orally active, selective and competitive α1-adrenoceptor antagonist. Alfuzosin relaxes the muscles of the prostate and bladder neck, aiding in urination. Alfuzosin can be used in study of benign prostatic hyperplasia (BPH).
体内研究:
Alfuzosin hydrochloride (10 mg/kg, p.o.; single) potently antagonizes phenylephrine-induced increases in urethral and arterial pressures up to 6 hours post dosing.Animal Model:Male Wistar rats (250-450 g).
Dosage:10 mg/kg
Administration:Oral administration; single.
Result:Increased prostatic concentrations to 4.1-8.6 times higher than plasma concentration.