产品
编 号:F055312
分子式:C19H18N3NaO5S
分子量:423.42
产品类型
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CAS No: 1173-88-2
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产品详情
生物活性:
Oxacillin sodium salt is an orally active synthetic penicillin with good bactericidal activity against staphylococci and other gram-positive pathogens.
体内研究:
Oxacillin (50-800 mg/kg; s.c.; once) shows curative dose (CD50) of 253.3 mg/kg in mice infected with Staphylococcus aureus Evans. The oral CD50 of Oxacillin is 187.2 mg/kg.Animal Model:CD-1 strain male albino mice infected with S. aureus Evans
Dosage:50, 100, 200, 400 and 800 mg/kg
Administration:Subcutaneous injection, once
Result:Showed therapeutic activity with CD50 of 253.3 mg/kg.
体外研究:
Oxacillin inhibits gram positive pathogens with MICs of 0.05, 0.09, 0.32 and 0.80 μg/mL against group A streptococci, Pneutnococci, susceptible staphylococci and penicillin-resistant staphylococci, respectively.The Oxacillin-resistant strains are highly resistant to other penicillins.