产品
编 号：F467473
分子式：C24H40O5
分子量：408.57
分子式：C24H40O5
分子量：408.57
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
100mg
400
In-stock
1g
560
In-stock
结构图
CAS No: 81-25-4
产品详情
生物活性：
Cholic acid is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion. Cholic acid is orally active.
体内研究：
Cholic acid(1% (w/w) Cholic acid-supplemented diet; p.o.; 14 days) decreases SHP (small heterodimer partner) protein expression, potentially via the upregulation of miR142-3p. Cholic acid increases CYP2D6 expression and activity.Animal Model:Tg-CYP2D6 adult male mice (8 weeks of age and weighing 20–25 g)
Dosage:1% (w/w) Cholic acid-supplemented diet
Administration:Oral, 14 days
Result:Decreases SHP expression and increased CYP2D6 activity.
体外研究：
Cholic acid (1 mg/mL, 30 min) competitively binds Na+/taurocholate cotransporting polypeptide (NTCP) on HepG2 cells and significantly inhibits the uptake of Cholic acid (CA)-nanoliposomes (LPs)-Doxorubicin (DOX)-HCl, which indicates that CA-LPs-DOX-HCl are also uptaken via NTCP-mediated endocytosis pathway.
Cholic acid is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion. Cholic acid is orally active.
体内研究：
Cholic acid(1% (w/w) Cholic acid-supplemented diet; p.o.; 14 days) decreases SHP (small heterodimer partner) protein expression, potentially via the upregulation of miR142-3p. Cholic acid increases CYP2D6 expression and activity.Animal Model:Tg-CYP2D6 adult male mice (8 weeks of age and weighing 20–25 g)
Dosage:1% (w/w) Cholic acid-supplemented diet
Administration:Oral, 14 days
Result:Decreases SHP expression and increased CYP2D6 activity.
体外研究：
Cholic acid (1 mg/mL, 30 min) competitively binds Na+/taurocholate cotransporting polypeptide (NTCP) on HepG2 cells and significantly inhibits the uptake of Cholic acid (CA)-nanoliposomes (LPs)-Doxorubicin (DOX)-HCl, which indicates that CA-LPs-DOX-HCl are also uptaken via NTCP-mediated endocytosis pathway.
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