产品
编 号：F467435
分子式：C26H45NO7S
分子量：515.7
分子式：C26H45NO7S
分子量：515.7
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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1mg
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5mg
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10mg
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25mg
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50mg
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100mg
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结构图
CAS No: 81-24-3
产品详情
生物活性：
Taurocholic acid (N-Choloyltaurine) has marked bioactive effects such as an inhibitory potential against hepatic artery ligation induced biliary damage by upregulation of VEGF-A expression. Taurocholic acid has immunoregulation effect.
体内研究：
Taurocholic acid (oral gavage, 100 mg/kg, 2 weeks) 可降低 C57BL/6 小鼠 (尾静脉注射 rAAV8-1.3HBV) 中 NK 和 CD3+CD8+ T 细胞的百分比来促进 HBV 复制。Taurocholic acid (饮食中 1%，1 周) 通过上调 VEGF-A 表达来阻止肝动脉结扎 (HAL) 诱导的胆管细胞损伤。Animal Model:C57BL/6 mice
Dosage:100-mg/kg
Administration:oral gavage, for 2 weeks after tail vein injection with rAAV8-1.3HBV for 6 weeks
Result:Reduced the percentage of NK and CD3+CD8+ T cells.Increases serum HBsAg, HBeAg, and HBV DNA levels.
体外研究：
Taurocholic acid (100 μM, 24 h) decreases the proportion of CD3+CD8+ T and NK cells in isolated PBMCs from HBeAg-positive CHB patients.Taurocholic acid (100 μM, 24 h) decreases IFN-α stimulated cytokine and cytotoxic granule levels (IFN-γ, TNF-α, granzyme B) in CD3+CD8+ T and NK cells.
Taurocholic acid (N-Choloyltaurine) has marked bioactive effects such as an inhibitory potential against hepatic artery ligation induced biliary damage by upregulation of VEGF-A expression. Taurocholic acid has immunoregulation effect.
体内研究：
Taurocholic acid (oral gavage, 100 mg/kg, 2 weeks) 可降低 C57BL/6 小鼠 (尾静脉注射 rAAV8-1.3HBV) 中 NK 和 CD3+CD8+ T 细胞的百分比来促进 HBV 复制。Taurocholic acid (饮食中 1%，1 周) 通过上调 VEGF-A 表达来阻止肝动脉结扎 (HAL) 诱导的胆管细胞损伤。Animal Model:C57BL/6 mice
Dosage:100-mg/kg
Administration:oral gavage, for 2 weeks after tail vein injection with rAAV8-1.3HBV for 6 weeks
Result:Reduced the percentage of NK and CD3+CD8+ T cells.Increases serum HBsAg, HBeAg, and HBV DNA levels.
体外研究：
Taurocholic acid (100 μM, 24 h) decreases the proportion of CD3+CD8+ T and NK cells in isolated PBMCs from HBeAg-positive CHB patients.Taurocholic acid (100 μM, 24 h) decreases IFN-α stimulated cytokine and cytotoxic granule levels (IFN-γ, TNF-α, granzyme B) in CD3+CD8+ T and NK cells.
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