产品
编 号：F467090
分子式：C21H23NO4S
分子量：385.48
分子式：C21H23NO4S
分子量：385.48
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
200mg
400
In-stock
500mg
560
In-stock
1g
864
In-stock
结构图
CAS No: 81110-73-8
产品详情
生物活性：
Racecadotril (Acetorphan) is a neutral endopeptidase (NEP) inhibitor. Racecadotril and its active metabolite Thiorphan inhibits purified NEP activity from mouse brain with Kis of 4500 and 6.1 nM, , respectively. Antidiarrheal agent.
体内研究：
In mice, following i.v. administration, Racecadotril is rapidly metabolized to Thiorphan; thus, 30?min after the injection only Thiorphan is recovered from the kidney whereas the parent compound Racecadotril is not detected. In rats 92% of a single-dose (10?mg/kg) of radioactively labeled Racecadotril is eliminated within 24?h.Racecadotril is a neutral endopeptidase (NEP) inhibitor with known antidiarrheal activity in animals. Orally administered Racecadotril (100 mg/kg ) shows efficacy in a rat model of castor oil-induced diarrhea.Animal Model:6-to-7-week-old male Wistar rats
Dosage:100 mg/kg
Administration:A single oral treatment; 30 minutes before castor oil administration.
Result:Significantly reduced stool output but did not prevent the occurrence of diarrhea (100% incidence).
Racecadotril (Acetorphan) is a neutral endopeptidase (NEP) inhibitor. Racecadotril and its active metabolite Thiorphan inhibits purified NEP activity from mouse brain with Kis of 4500 and 6.1 nM, , respectively. Antidiarrheal agent.
体内研究：
In mice, following i.v. administration, Racecadotril is rapidly metabolized to Thiorphan; thus, 30?min after the injection only Thiorphan is recovered from the kidney whereas the parent compound Racecadotril is not detected. In rats 92% of a single-dose (10?mg/kg) of radioactively labeled Racecadotril is eliminated within 24?h.Racecadotril is a neutral endopeptidase (NEP) inhibitor with known antidiarrheal activity in animals. Orally administered Racecadotril (100 mg/kg ) shows efficacy in a rat model of castor oil-induced diarrhea.Animal Model:6-to-7-week-old male Wistar rats
Dosage:100 mg/kg
Administration:A single oral treatment; 30 minutes before castor oil administration.
Result:Significantly reduced stool output but did not prevent the occurrence of diarrhea (100% incidence).
产品资料
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