产品
编 号：F466993
分子式：C22H32O5
分子量：376.49
分子式：C22H32O5
分子量：376.49
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CAS No: 810668-37-2
产品详情
生物活性：
Resolvin D2 is a metabolite of docosahexaenoic acid (DHA), with anti-inflammatory, anti-infective activities. Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis. Resolvin D2 is a remarkably potent inhibitor of TRPV1 (IC50 = 0.1 nM) and TRPA1 (IC50 = 2 nM) in primary sensory neurons.
体内研究：
Resolvin D2 induces active resolution of inflammation with pulp-like tissue regeneration after root canal infection and thus maybe suitable for treating periapical lesions. Resolvin D2 decreases leukocyte:endothelial interactions in vivo by endothelial-dependent nitric oxide production, and direct modulation of leukocyte adhesion receptor expression. Peripheral administration of Resolvin D2 (10 ng; Intraplantar administration) potently inhibits inflammatory pain.Animal Model:Adult CD1 mice (male, 8–10 weeks)
Dosage:10 ng
Administration:Intraplantar administration
Result:Inhibited inflammatory pain.
Resolvin D2 is a metabolite of docosahexaenoic acid (DHA), with anti-inflammatory, anti-infective activities. Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis. Resolvin D2 is a remarkably potent inhibitor of TRPV1 (IC50 = 0.1 nM) and TRPA1 (IC50 = 2 nM) in primary sensory neurons.
体内研究：
Resolvin D2 induces active resolution of inflammation with pulp-like tissue regeneration after root canal infection and thus maybe suitable for treating periapical lesions. Resolvin D2 decreases leukocyte:endothelial interactions in vivo by endothelial-dependent nitric oxide production, and direct modulation of leukocyte adhesion receptor expression. Peripheral administration of Resolvin D2 (10 ng; Intraplantar administration) potently inhibits inflammatory pain.Animal Model:Adult CD1 mice (male, 8–10 weeks)
Dosage:10 ng
Administration:Intraplantar administration
Result:Inhibited inflammatory pain.
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