产品
编 号：F005600
分子式：C20H23N3O2
分子量：337.42
分子式：C20H23N3O2
分子量：337.42
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 101246-66-6
产品详情
生物活性：
Phenserine ((-)-Eseroline phenylcarbamate) is a derivative of Physostigmine and is a potent, noncompetitive, long-acting and selective AChE inhibitor. Phenserine reduces β-amyloid precursor protein (APP) and β-amyloid peptide (Aβ) formation. Phenserine improves cognitive performance and attenuates the progression of Alzheimer's disease.
体内研究：
Phenserine (1-4 mg/kg；腹膜内注射；持续 4 天；雄性 Fischer-344 大鼠) 处理可改善空间记忆任务中胆碱能功能受损时的学习。Animal Model:Male Fischer-344 rats (5 months old) induced by scopolamine
Dosage:1 mg/kg, 2 mg/kg, 4 mg/kg
Administration:Intraperitoneal injection; for 4 days
Result:Improved morris water maze performance of scopolamine-treated rats..
体外研究：
Phenserine (1-25 μM；48 小时；CHO APP751SW 细胞)，10 μM Phenserine 处理的 CHO APP751SW 细胞显示细胞减少 18.6%，而 25 μM Phenserine 的浓度使 APP 水平降低了 51.4%。
Phenserine ((-)-Eseroline phenylcarbamate) is a derivative of Physostigmine and is a potent, noncompetitive, long-acting and selective AChE inhibitor. Phenserine reduces β-amyloid precursor protein (APP) and β-amyloid peptide (Aβ) formation. Phenserine improves cognitive performance and attenuates the progression of Alzheimer's disease.
体内研究：
Phenserine (1-4 mg/kg；腹膜内注射；持续 4 天；雄性 Fischer-344 大鼠) 处理可改善空间记忆任务中胆碱能功能受损时的学习。Animal Model:Male Fischer-344 rats (5 months old) induced by scopolamine
Dosage:1 mg/kg, 2 mg/kg, 4 mg/kg
Administration:Intraperitoneal injection; for 4 days
Result:Improved morris water maze performance of scopolamine-treated rats..
体外研究：
Phenserine (1-25 μM；48 小时；CHO APP751SW 细胞)，10 μM Phenserine 处理的 CHO APP751SW 细胞显示细胞减少 18.6%，而 25 μM Phenserine 的浓度使 APP 水平降低了 51.4%。
产品资料
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