产品
编 号：F466609
分子式：C46H75NO14
分子量：866.09
分子式：C46H75NO14
分子量：866.09
产品类型
规格
价格
是否有货
25μg
询价
询价
50μg
询价
询价
结构图
CAS No: 80890-47-7
产品详情
生物活性：
Concanamycin A (Folimycin; Antibiotic X 4357B) is a macrolide antibiotic, a vacuolar type H+-ATPase (V-ATPase) inhibitor. Concanamycin A is also an inhibitor of lysosomal acidification, can be used to T cell-mediated inflammation research-.
体内研究：
Concanamycin A (15 mg/kg; i.v.; 0, 10 or 24 h prior to sacrifice) induces T cell-mediated hepatitis in mice.Animal Model:Wild type mice
Dosage:15 mg/kg
Administration:Intravenous injection 0, 10 or 24 h prior to sacrifice
Result:Resulted significant liver injury as demonstrated by serum transaminase levels, inflammatory cell infiltrate, hepatocyte apoptosis, and expression of several cytokines including interleukin 4 (IL4) and interferon gamma (IFNγ) at 10 h and 24 h following administration.
体外研究：
Concanamycin A can come from S. diastatochromogenes, as a microbial metabolite with immunomodulatory activity.?Concanamycin A (100 nM; 0-20 h) results DNA fragmentation in CD4+ and selectively induces CD8+ T cells rapid cell death between normal and the immunized mice source, while CD8+ population in mice immunized is more sensitive.?Concanamycin A (3-50 nM; 16 h) inhibits LPS-induced NO production in elicited peritoneal macrophages, but (25 nM; 7 h) doesn’t inhibit LPS-induced TNF-α production.?Concanamycin A (0.01 nM-1 nM) inhibits the acidification of rat liver lysosomes (IC50 =0.061 nM), and inhibits oleate incorporation into cholesteryl ester (IC50 =14 nM).
Concanamycin A (Folimycin; Antibiotic X 4357B) is a macrolide antibiotic, a vacuolar type H+-ATPase (V-ATPase) inhibitor. Concanamycin A is also an inhibitor of lysosomal acidification, can be used to T cell-mediated inflammation research-.
体内研究：
Concanamycin A (15 mg/kg; i.v.; 0, 10 or 24 h prior to sacrifice) induces T cell-mediated hepatitis in mice.Animal Model:Wild type mice
Dosage:15 mg/kg
Administration:Intravenous injection 0, 10 or 24 h prior to sacrifice
Result:Resulted significant liver injury as demonstrated by serum transaminase levels, inflammatory cell infiltrate, hepatocyte apoptosis, and expression of several cytokines including interleukin 4 (IL4) and interferon gamma (IFNγ) at 10 h and 24 h following administration.
体外研究：
Concanamycin A can come from S. diastatochromogenes, as a microbial metabolite with immunomodulatory activity.?Concanamycin A (100 nM; 0-20 h) results DNA fragmentation in CD4+ and selectively induces CD8+ T cells rapid cell death between normal and the immunized mice source, while CD8+ population in mice immunized is more sensitive.?Concanamycin A (3-50 nM; 16 h) inhibits LPS-induced NO production in elicited peritoneal macrophages, but (25 nM; 7 h) doesn’t inhibit LPS-induced TNF-α production.?Concanamycin A (0.01 nM-1 nM) inhibits the acidification of rat liver lysosomes (IC50 =0.061 nM), and inhibits oleate incorporation into cholesteryl ester (IC50 =14 nM).
产品资料
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