产品
编 号：F466312
分子式：C19H16N2O5
分子量：352.34
分子式：C19H16N2O5
分子量：352.34
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
500
In-stock
5mg
300
In-stock
10mg
500
In-stock
50mg
1000
In-stock
100mg
询价
In-stock
结构图
CAS No: 808118-40-3
产品详情
生物活性：
Roxadustat is an orally active hypoxia-inducible factor (HIF) prolyl-hydroxylase (PHD) inhibitor (HIF-PHI) that promotes erythropoiesis through increasing endogenous erythropoietin, improving iron regulation, and reducing hepcidin.
体内研究：
Roxadustat (50 mg/kg; i.p.; daily for 7 days) protects the survival of motor neurons and improves recovery from spinal cord injury.Animal Model:12-week female C57BL/6 mice
Dosage:50 mg/kg
Administration:Intraperitoneal injection; daily for 7 days
Result:Protected the survival of motor neurons and improved recovery from spinal cord injury.
体外研究：
Roxadustat (5-50 μM; 6 hours) significantly inhibits TBHP-induced apoptosis in PC12 cells.Roxadustat (50 μM; 6 hours) stabilizes HIF-1α protein expression in PC12 cells.
Roxadustat is an orally active hypoxia-inducible factor (HIF) prolyl-hydroxylase (PHD) inhibitor (HIF-PHI) that promotes erythropoiesis through increasing endogenous erythropoietin, improving iron regulation, and reducing hepcidin.
体内研究：
Roxadustat (50 mg/kg; i.p.; daily for 7 days) protects the survival of motor neurons and improves recovery from spinal cord injury.Animal Model:12-week female C57BL/6 mice
Dosage:50 mg/kg
Administration:Intraperitoneal injection; daily for 7 days
Result:Protected the survival of motor neurons and improved recovery from spinal cord injury.
体外研究：
Roxadustat (5-50 μM; 6 hours) significantly inhibits TBHP-induced apoptosis in PC12 cells.Roxadustat (50 μM; 6 hours) stabilizes HIF-1α protein expression in PC12 cells.
产品资料
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