产品
编 号：F466169
分子式：C19H20ClNO2
分子量：329.82
分子式：C19H20ClNO2
分子量：329.82
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CAS No: 80751-65-1
产品详情
生物活性：
SKF-82958 ((±)-SKF 82958) is a dopamine D1 receptor full agonist (K0.5=4 nM), displays selective for D1 over D2 receptors (K0.5=73 nM). SKF-82958 induces dopamine D1 receptor-dependent adenylate cyclase activity in rat striatal membranes (EC50=491 nM).
体内研究：
SKF-82958 ((±)-SKF 82958) (0.003-0.1 mg/kg; i.p.) results in dose-dependent increases in responding on the SKF-82958 appropriate lever, with full substitution following administration of the SKF-82958 training dose 0.03 mg/kg. Increasing the dose of SKF-82958 also results in a significant reduction in response rate.SKF-82958 (0.5-2.0 mg/kg; i.p) significantly suppresses pilocarpine-induced jaw movements.Animal Model:Male Sprague-Dawley rats
Dosage:0.5-2.0 mg/kg
Administration:I.p
Result:Significantly reduced the number of tremulous jaw movements induced by 4.0 mg/kg pilocarpine.
SKF-82958 ((±)-SKF 82958) is a dopamine D1 receptor full agonist (K0.5=4 nM), displays selective for D1 over D2 receptors (K0.5=73 nM). SKF-82958 induces dopamine D1 receptor-dependent adenylate cyclase activity in rat striatal membranes (EC50=491 nM).
体内研究：
SKF-82958 ((±)-SKF 82958) (0.003-0.1 mg/kg; i.p.) results in dose-dependent increases in responding on the SKF-82958 appropriate lever, with full substitution following administration of the SKF-82958 training dose 0.03 mg/kg. Increasing the dose of SKF-82958 also results in a significant reduction in response rate.SKF-82958 (0.5-2.0 mg/kg; i.p) significantly suppresses pilocarpine-induced jaw movements.Animal Model:Male Sprague-Dawley rats
Dosage:0.5-2.0 mg/kg
Administration:I.p
Result:Significantly reduced the number of tremulous jaw movements induced by 4.0 mg/kg pilocarpine.
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