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编 号：F466068
分子式：C37H51N9O10S
分子量：813.92
分子式：C37H51N9O10S
分子量：813.92
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CAS No: 80714-61-0
产品详情
生物活性：
Semax is a nootropic neuroprotective peptide. Semax can be used in the research of brain stroke.
体内研究：
Semax (100 μg/kg, i.p.) promotes the formation and functioning of the vascular system in Ischemia?(pMCAO) rats.Semax (50 μg and 250 μg, 100 μL/kg, intranasal inhalation) increases levels of b BDNF protein in rat basal forebrain.Animal Model:Ischemia?(pMCAO) rats.
Dosage:100 μg/kg
Administration:Intraperitoneal injections (i.p.), performed 15 min, 1, 4 and 8 h after permanent middle cerebral artery occlusion (pMCAO).
Result:Increased the immune response (upregulation of transcripts).
Animal Model:Rats
Dosage:50 μg, 250 μg, 100 μL/kg
Administration:Intranasal inhalation
Result:Increased levels of brain-derived neurotrophic factor (BDNF) protein in rat basal forebrain.
体外研究：
Semax (25 μM and 100 μM, 48 h) reduces the Abeta oligomers (100 μM) levels.Semax (100 nM) increase survival of cholinergic basal forebrain neurons.Semax (100 nM) stimulates activity of choline acetyltransferase in dissociated basal forebrain tissue culture.Semax (10 μM, 24 h) stimulates the synthesis of brain-derived neurotrophic factor (BDNF) in astrocytes cultured from rat basal forebrain.
Semax is a nootropic neuroprotective peptide. Semax can be used in the research of brain stroke.
体内研究：
Semax (100 μg/kg, i.p.) promotes the formation and functioning of the vascular system in Ischemia?(pMCAO) rats.Semax (50 μg and 250 μg, 100 μL/kg, intranasal inhalation) increases levels of b BDNF protein in rat basal forebrain.Animal Model:Ischemia?(pMCAO) rats.
Dosage:100 μg/kg
Administration:Intraperitoneal injections (i.p.), performed 15 min, 1, 4 and 8 h after permanent middle cerebral artery occlusion (pMCAO).
Result:Increased the immune response (upregulation of transcripts).
Animal Model:Rats
Dosage:50 μg, 250 μg, 100 μL/kg
Administration:Intranasal inhalation
Result:Increased levels of brain-derived neurotrophic factor (BDNF) protein in rat basal forebrain.
体外研究：
Semax (25 μM and 100 μM, 48 h) reduces the Abeta oligomers (100 μM) levels.Semax (100 nM) increase survival of cholinergic basal forebrain neurons.Semax (100 nM) stimulates activity of choline acetyltransferase in dissociated basal forebrain tissue culture.Semax (10 μM, 24 h) stimulates the synthesis of brain-derived neurotrophic factor (BDNF) in astrocytes cultured from rat basal forebrain.
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