产品
编 号：F465328
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是否有货
5mg
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10mg
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25mg
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50mg
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100mg
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CAS No: 80449-31-6
产品详情
生物活性：
Ulinastatin (Uristatin) is a trypsin and serine protease inhibitor. Ulinastatin is the main protein binding inhibitor of various trypsin, chymotrypsin, and various pancreatic proteases. Ulinastatin shows neuroprotective, anti-inflammatory, anti-apoptotic, anti-oxidant effects.
体内研究：
Ulinastatin（10000 U/kg；静脉注射；两次）显着保护动物免受 LPS 诱导的急性肺损伤 (ALI)，降低肺湿/干重比、ALI 评分、总细胞、中性粒细胞、巨噬细胞、髓过氧化物酶活性和丙二醛含量 、与肺组织学损伤相关的因素。Animal Model:Male C57BL/6 mice (8-10 weeks old, 18-22 g)
Dosage:10000 U/kg
Administration:i.v.; twice (1 h before and 6 h after LPS treatment)
Result:Significantly protected animals from LPS-induced ALI.
体外研究：
Ulinastatin（500-5000 U；24 小时）可显着减弱 LPS 刺激的 BEAS-2B 细胞中的 TLR4 表达和 NF-κB 激活。
Ulinastatin (Uristatin) is a trypsin and serine protease inhibitor. Ulinastatin is the main protein binding inhibitor of various trypsin, chymotrypsin, and various pancreatic proteases. Ulinastatin shows neuroprotective, anti-inflammatory, anti-apoptotic, anti-oxidant effects.
体内研究：
Ulinastatin（10000 U/kg；静脉注射；两次）显着保护动物免受 LPS 诱导的急性肺损伤 (ALI)，降低肺湿/干重比、ALI 评分、总细胞、中性粒细胞、巨噬细胞、髓过氧化物酶活性和丙二醛含量 、与肺组织学损伤相关的因素。Animal Model:Male C57BL/6 mice (8-10 weeks old, 18-22 g)
Dosage:10000 U/kg
Administration:i.v.; twice (1 h before and 6 h after LPS treatment)
Result:Significantly protected animals from LPS-induced ALI.
体外研究：
Ulinastatin（500-5000 U；24 小时）可显着减弱 LPS 刺激的 BEAS-2B 细胞中的 TLR4 表达和 NF-κB 激活。
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