产品
编 号：F465324
分子式：C99H155N31O23
分子量：2147.48
分子式：C99H155N31O23
分子量：2147.48
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 80448-90-4
产品详情
生物活性：
Dynorphin A is an endogenous opioid peptide involved in inhibitory neurotransmission in the central nervous system (CNS). Dynorphin A is a highy potent kappa opioid receptor (KOR) agonist, and is also an agonist for other opioid receptors, such as mu (MOR) and delta (DOR). Dynorphin A can induce neuronal death, and can be used in the research of neurological disease.
体内研究：
Dynorphin A (intracerebroventricular injection, 1 μg of 2 μL, a single dose) inhibits vasopressin (VP) release in 24 h water-deprived male rats.Dynorphin A (intracerebroventricular injection, 500 pmol/5 μL per day for 4 d) alleviates stress-induced behavioral impairments in ddY mice accompanied by regulation of the 5-HTergic system in the brain.Animal Model:24 h water-deprived male rats
Dosage:1 μg of 2 μL
Administration:Intracerebroventricular injection
Result:Inhibited vasopressin (VP) release 30 min upon injection.
Animal Model:Male ddY mice
Dosage:15, 150, 1500 pmol/5 μL per day for 4 days
Administration:Intracerebroventricular injection
Result:Attenuated the repeated stress-induced escape failures from the shock.
体外研究：
Dynorphin A (10 μM, 4 h/72 h) increases caspase-3 activity and the level of cytochrome c released from mitochondria in mouse striatal neurons, and induces neuronal death.dynorphin A (33 μM, 4 h) elevates [Ca2+]i and causes a significant loss of neurons.dynorphin A (1 μM) inhibits the release of vasopressin (VP) from the isolated neural lobe.
Dynorphin A is an endogenous opioid peptide involved in inhibitory neurotransmission in the central nervous system (CNS). Dynorphin A is a highy potent kappa opioid receptor (KOR) agonist, and is also an agonist for other opioid receptors, such as mu (MOR) and delta (DOR). Dynorphin A can induce neuronal death, and can be used in the research of neurological disease.
体内研究：
Dynorphin A (intracerebroventricular injection, 1 μg of 2 μL, a single dose) inhibits vasopressin (VP) release in 24 h water-deprived male rats.Dynorphin A (intracerebroventricular injection, 500 pmol/5 μL per day for 4 d) alleviates stress-induced behavioral impairments in ddY mice accompanied by regulation of the 5-HTergic system in the brain.Animal Model:24 h water-deprived male rats
Dosage:1 μg of 2 μL
Administration:Intracerebroventricular injection
Result:Inhibited vasopressin (VP) release 30 min upon injection.
Animal Model:Male ddY mice
Dosage:15, 150, 1500 pmol/5 μL per day for 4 days
Administration:Intracerebroventricular injection
Result:Attenuated the repeated stress-induced escape failures from the shock.
体外研究：
Dynorphin A (10 μM, 4 h/72 h) increases caspase-3 activity and the level of cytochrome c released from mitochondria in mouse striatal neurons, and induces neuronal death.dynorphin A (33 μM, 4 h) elevates [Ca2+]i and causes a significant loss of neurons.dynorphin A (1 μM) inhibits the release of vasopressin (VP) from the isolated neural lobe.
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