产品
编 号：F465224
分子式：C20H21CaN7O7
分子量：511.5
分子式：C20H21CaN7O7
分子量：511.5
产品类型
规格
价格
是否有货
100mg
询价
询价
500mg
询价
询价
1g
询价
询价
2g
询价
询价
结构图
CAS No: 80433-71-2
产品详情
生物活性：
Levoleucovorin Calcium (Calcium levofolinate), a levo isoform of Leucovorin Calcium (HY-13664), possesses antineoplastic effects. Levoleucovorin Calcium is also an augmentor of 5-fluorouracil (HY-90006) cytotoxicity against cancer.
体内研究：
Levoleucovorin Calcium (6, 20 or 60 mg/kg/day; i.v.; for 4 weeks) enhances the toxicity of 5-Fluorouracil.Animal Model:Crj:CD(SD)BR rats (5 weeks)
Dosage:6, 20 or 60 mg/kg/day
Administration:i.v.; for 4 weeks (combined with 10 mg/kg/day 5-Fluorouracil)
Result:Decreased the RBC counts, increased extramedullary hematopoiesis and enhanced the suppression of lymphatic organs.Induced the potentiation in the toxicity of 5-Fluorouracil appeared to be mainly immuno-suppression and myelosuppression, which were related to the anti-tumor activity of 5-Fluorouracil.
Levoleucovorin Calcium (Calcium levofolinate), a levo isoform of Leucovorin Calcium (HY-13664), possesses antineoplastic effects. Levoleucovorin Calcium is also an augmentor of 5-fluorouracil (HY-90006) cytotoxicity against cancer.
体内研究：
Levoleucovorin Calcium (6, 20 or 60 mg/kg/day; i.v.; for 4 weeks) enhances the toxicity of 5-Fluorouracil.Animal Model:Crj:CD(SD)BR rats (5 weeks)
Dosage:6, 20 or 60 mg/kg/day
Administration:i.v.; for 4 weeks (combined with 10 mg/kg/day 5-Fluorouracil)
Result:Decreased the RBC counts, increased extramedullary hematopoiesis and enhanced the suppression of lymphatic organs.Induced the potentiation in the toxicity of 5-Fluorouracil appeared to be mainly immuno-suppression and myelosuppression, which were related to the anti-tumor activity of 5-Fluorouracil.
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