产品
编 号：F465200
分子式：C47H80O18
分子量：933.13
分子式：C47H80O18
分子量：933.13
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
480
In-stock
10mg
720
In-stock
结构图
CAS No: 80418-24-2
产品详情
生物活性：
Notoginsenoside R1 (Sanchinoside R1), a saponin, is isolated from P. notoginseng. Notoginsenoside R1 exhibits anti-oxidation, anti-inflammatory, anti-angiogenic, and anti-apoptosis activities. Notoginsenoside R1 provides cardioprotection against ischemia/reperfusion (I/R) injury. Notoginsenoside R1 also provides neuroprotection in H2O2-induced oxidative damage in PC12 cells.
体内研究：
Notoginsenoside R1 (5 mg/kg/h；通过右颈静脉输注) 增加大鼠的红细胞速度，减少贴壁白细胞的数量并抑制肥大细胞脱颗粒和细胞因子升高。Animal Model:Male Sprague-Dawley (SD) rats (200-250 g)
Dosage:5 mg/kg/h
Administration:Infused 20 min before LPS infusion via the right jugular vein
Result:Ameliorated the LPS-induced reduction in the mesenteric venular shear rate to some extent.Attenuated the LPS-induced adhesion of leukocytes to the venular wall.Inhibited mast cell degranulation and cytokine elevation.
体外研究：
Notoginsenoside R1 (2.5 -80 μM；24 小时) 抑制 H9c2 心肌细胞缺氧复氧 (H/R) 诱导的细胞死亡、细胞内 ROS 积累和线粒体膜去极化。Notoginsenoside R1 (5 -20 μM；24 h) 以浓度依赖性方式抑制H/R诱导的H9c2心肌细胞凋亡。Notoginsenoside R1 (1-100 μM；24 h) 剂量依赖性地保护 PC12 细胞和原代神经元免受 Aβ 诱导的细胞死亡和细胞凋亡。Notoginsenoside R1 (10 μM；24 h) 抑制 Aβ25-35 诱导 PC12 细胞产生 ROS、线粒体损伤和 MAPK 激活。
Notoginsenoside R1 (Sanchinoside R1), a saponin, is isolated from P. notoginseng. Notoginsenoside R1 exhibits anti-oxidation, anti-inflammatory, anti-angiogenic, and anti-apoptosis activities. Notoginsenoside R1 provides cardioprotection against ischemia/reperfusion (I/R) injury. Notoginsenoside R1 also provides neuroprotection in H2O2-induced oxidative damage in PC12 cells.
体内研究：
Notoginsenoside R1 (5 mg/kg/h；通过右颈静脉输注) 增加大鼠的红细胞速度，减少贴壁白细胞的数量并抑制肥大细胞脱颗粒和细胞因子升高。Animal Model:Male Sprague-Dawley (SD) rats (200-250 g)
Dosage:5 mg/kg/h
Administration:Infused 20 min before LPS infusion via the right jugular vein
Result:Ameliorated the LPS-induced reduction in the mesenteric venular shear rate to some extent.Attenuated the LPS-induced adhesion of leukocytes to the venular wall.Inhibited mast cell degranulation and cytokine elevation.
体外研究：
Notoginsenoside R1 (2.5 -80 μM；24 小时) 抑制 H9c2 心肌细胞缺氧复氧 (H/R) 诱导的细胞死亡、细胞内 ROS 积累和线粒体膜去极化。Notoginsenoside R1 (5 -20 μM；24 h) 以浓度依赖性方式抑制H/R诱导的H9c2心肌细胞凋亡。Notoginsenoside R1 (1-100 μM；24 h) 剂量依赖性地保护 PC12 细胞和原代神经元免受 Aβ 诱导的细胞死亡和细胞凋亡。Notoginsenoside R1 (10 μM；24 h) 抑制 Aβ25-35 诱导 PC12 细胞产生 ROS、线粒体损伤和 MAPK 激活。
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