产品
编 号：F464235
分子式：C18H22O4
分子量：302.36
分子式：C18H22O4
分子量：302.36
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CAS No: 80226-00-2
产品详情
生物活性：
Enterodiol is transformed by human intestinal bacteria from lignans contained in various whole-grain cereals, nuts, legumes, flaxseed, and vegetables. Enterodiol has an apoptotic effect in colorectal cancer (CRC) cells. Anti-cancer activities.
体内研究：
Enterodiol (1 mg/kg; intra-tumor injection method; once every other day until day 32) suppresses tumor markedly.Animal Model:4-8 weeks old female BALB/c nude mice
Dosage:1 mg/kg
Administration:Intra-tumor injection method; once every other day until day 32
Result:A significant reduction in the tumor volume in the experimental groups compared to the PBS group.
体外研究：
Enterodiol (0-100 μM; 24-72 hours) results in an apoptosis rate of up to 40% in CT26 cells. Enterodiol shows no cytotoxicity toward RAW264.7 macrophages.Enterodiol (0-100 μM; 24-48 hours) also suppresses the migration of CRC cells in a concentration-dependent manner. The phosphorylation of ERK, JNK, and p38 is down-regulated with Enterodiol treatment. Enterodiol (0-100 μM; 48 hours) decreases the expression levels of anti-apoptotic proteins in CRC cells.
Enterodiol is transformed by human intestinal bacteria from lignans contained in various whole-grain cereals, nuts, legumes, flaxseed, and vegetables. Enterodiol has an apoptotic effect in colorectal cancer (CRC) cells. Anti-cancer activities.
体内研究：
Enterodiol (1 mg/kg; intra-tumor injection method; once every other day until day 32) suppresses tumor markedly.Animal Model:4-8 weeks old female BALB/c nude mice
Dosage:1 mg/kg
Administration:Intra-tumor injection method; once every other day until day 32
Result:A significant reduction in the tumor volume in the experimental groups compared to the PBS group.
体外研究：
Enterodiol (0-100 μM; 24-72 hours) results in an apoptosis rate of up to 40% in CT26 cells. Enterodiol shows no cytotoxicity toward RAW264.7 macrophages.Enterodiol (0-100 μM; 24-48 hours) also suppresses the migration of CRC cells in a concentration-dependent manner. The phosphorylation of ERK, JNK, and p38 is down-regulated with Enterodiol treatment. Enterodiol (0-100 μM; 48 hours) decreases the expression levels of anti-apoptotic proteins in CRC cells.
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