产品
编 号：F055035
分子式：C25H28Cl2N2O
分子量：443.41
分子式：C25H28Cl2N2O
分子量：443.41
产品类型
规格
价格
是否有货
结构图
CAS No: 1173022-77-9
产品详情
生物活性：
BRL-15572 hydrochloride is a selective antagonist of h5-HT1D, displays high affinity for h5-HT1D receptors. BRL-15572 hydrochloride could be useful pharmacological agents to characterise 5-HT1D receptor mediated responses.
体内研究：
BRL-15572 prevents (-)-epicatechin-induced antinociception in the formalin test.BRL-15572 (0.3-100.0 mg/kg; i.p.) is inactive and BRL-15572 (0.1-10 mg/kg; i.p.) has no effect on body temperature the guinea pig.
体外研究：
BRL-15572 has 60-fold higher affinity for h5-HT1D (pKi=7.9) than 5-HT1B receptors on human receptors expressed in CHO cells.BRL-15572 (0.1 nM-10 μM) stimulates [35S]GTPγS binding in CHO cell membranes expressing h5-HT1B and h5-HT1D receptors.
BRL-15572 hydrochloride is a selective antagonist of h5-HT1D, displays high affinity for h5-HT1D receptors. BRL-15572 hydrochloride could be useful pharmacological agents to characterise 5-HT1D receptor mediated responses.
体内研究：
BRL-15572 prevents (-)-epicatechin-induced antinociception in the formalin test.BRL-15572 (0.3-100.0 mg/kg; i.p.) is inactive and BRL-15572 (0.1-10 mg/kg; i.p.) has no effect on body temperature the guinea pig.
体外研究：
BRL-15572 has 60-fold higher affinity for h5-HT1D (pKi=7.9) than 5-HT1B receptors on human receptors expressed in CHO cells.BRL-15572 (0.1 nM-10 μM) stimulates [35S]GTPγS binding in CHO cell membranes expressing h5-HT1B and h5-HT1D receptors.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备