产品
编 号:F462881
分子式:C11H15ClO2
分子量:214.69
产品类型
结构图
CAS No: 79-93-6
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生物活性:
Phenaglycodol belongs to the group of butanediolsa with anxiolytic and anticonvulsant porperties. Phenaglycodol has orally bioactivity.
体内研究:
Phenaglycodol (20 mg/kg, 腹腔注射,1次) 对猫有抗癫痫作用。Phenaglycodol (55-80 mg /kg, 腹腔注射, 1次) 对小鼠有抗癫痫作用。Phenaglycodol (50-100 mg/kg, 灌胃, 1次) 对猴子有抗癫痫作用。Phenaglycodol (130 mg/kg, 腹腔注射, 1次) 可降低血清和脑中Meprobamate 的浓度。Animal Model: Cat
Dosage:20 mg/kg
Administration:Intraperitoneal Injection (i.p.)
Result:Showed that cat became quiet.
Animal Model:Monkey
Dosage:50-100 mg/kg
Administration:Intragastric Gavage (i.g.)
Result:Showed that monkey became less aggressive or less fearful.
Animal Model:Mice
Dosage:55-80 mg/kg
Administration:Intraperitoneal Injection (i.p.)
Result:Showed a reduction in spontaneous activity and sit quietly.
Animal Model:Female Rats(Sprague-Dawley, 170g)
Dosage:130 mg/kg
Administration:Intraperitoneal Injection (i.p.)
Result:Showed that the decrease of Meprobamate concentration in the serum and brain of the pretrealed rats was more rapid than that in control rats.