产品
编 号:F462589
分子式:C9H17NO5
分子量:219.23
产品类型
结构图
CAS No: 79-83-4
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产品详情
生物活性:
D-Pantothenic acid (Pantothenate) is an essential trace nutrient that functions as the obligate precursor of coenzyme A (CoA). D-Pantothenic acid plays key roles in myriad biological processes, including many that regulate carbohydrate, lipid, protein, and nucleic acid metabolism.
体内研究:
Pantothenic acid (PTA; 3x10, 3x100, and 3x300 mg/kg) decreases Valproic acid (VPA; 300, 400, and 500 mg/kg, s.c.)-induced neural tube defects in mice.Animal Model:Female ICR mice weighing 29-35 g
Dosage:3x10, 3x100, and 3x300 mg/kg (10 mL/kg, volume administered)
Administration:Injected intraperitoneally (i.p.) on day 8.5 of gestation
Result:Significantly reduced VPA (300, 400, and 500 mg/kg, s.c.)-induced exencephaly, while none of the other external malformations such as open eyelid or skeletal malformations such as fused, absent, or bifurcated ribs and fused thoracic vertebrae and fused sternebrae were reduced.
体外研究:
D-Pantothenic acid sodium is a precursor to coenzyme A and is primarily involved in energy production and lipid metabolism through the TCA cycle and the β-oxidation pathway, respectively.