产品
编 号：F462302
分子式：C22H31F3N2O3
分子量：428.49
分子式：C22H31F3N2O3
分子量：428.49
产品类型
规格
价格
是否有货
结构图
CAS No: 796885-38-6
产品详情
生物活性：
MK-4541 is an orally active and selective androgen receptor (AR) modulator. MK-4541 acts as an antagonist to inhibit 5α-reductase. MK-4541 inhibits proliferation and induces apoptosis in AR positive prostate cancer cells. MK-4541 significantly inhibited the growth of R3327-G prostate tumors in xenograft mouse model.
体内研究：
MK-4541 (100 mg/kg; 每天1次，每周5次，持续5周) 抑制含 R-3327-G 细胞的无胸腺裸鼠前列腺肿瘤生长。MK-4541 (100 mg/kg, 200 mg/kg; 每周5次，持续5周) 对精囊具有抗雄激素作用，降低完好男性的血浆睾酮浓度，并抑制 Ki67 表达。MK-4541 (15 mg/kg, 50 mg/kg; 每周5次，持续8周) 导致成年阉割小鼠肌肉骨骼质量和功能的损失。Animal Model:R3327-G prostate tumors in xenograft mouse model
Dosage:25 mg/kg, 50 mg/kg, 100 mg/kg, 200 mg/kg
Administration:Oral gavage; once daily, 5 times per week for 5 weeks
Result:Significantly inhibited tumor growth at 100 mg/kg, as well as reducing plasma testosterone concentration and Ki67 expression.
MK-4541 is an orally active and selective androgen receptor (AR) modulator. MK-4541 acts as an antagonist to inhibit 5α-reductase. MK-4541 inhibits proliferation and induces apoptosis in AR positive prostate cancer cells. MK-4541 significantly inhibited the growth of R3327-G prostate tumors in xenograft mouse model.
体内研究：
MK-4541 (100 mg/kg; 每天1次，每周5次，持续5周) 抑制含 R-3327-G 细胞的无胸腺裸鼠前列腺肿瘤生长。MK-4541 (100 mg/kg, 200 mg/kg; 每周5次，持续5周) 对精囊具有抗雄激素作用，降低完好男性的血浆睾酮浓度，并抑制 Ki67 表达。MK-4541 (15 mg/kg, 50 mg/kg; 每周5次，持续8周) 导致成年阉割小鼠肌肉骨骼质量和功能的损失。Animal Model:R3327-G prostate tumors in xenograft mouse model
Dosage:25 mg/kg, 50 mg/kg, 100 mg/kg, 200 mg/kg
Administration:Oral gavage; once daily, 5 times per week for 5 weeks
Result:Significantly inhibited tumor growth at 100 mg/kg, as well as reducing plasma testosterone concentration and Ki67 expression.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备