产品
编 号：F461142
分子式：C20H17FN8
分子量：388.4
分子式：C20H17FN8
分子量：388.4
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规格
价格
是否有货
10mM*1mL in DMSO
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1mg
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5mg
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10mg
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25mg
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50mg
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100mg
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结构图
CAS No: 792184-90-8
产品详情
生物活性：
ASP2905 is a potent and selective potassium channel Kv12.2 inhibitor encoded by the Kcnh3/BEC1 gene. ASP2905 can cross the blood-brain barrier and has antipsychotic activities.
体内研究：
ASP2905 treatment inhibits hyperlocomotion induced by Phencyclidine. And significantly ameliorates Phencyclidine-induced prolongation of immobility time in mice subjected to the forced swimming test.Animal Model:Male ddY mice (aged 4-5 weeks) injected with Phencyclidine hydrochloride (PCP)
Dosage:0.01 mg/kg, 0.03 mg/kg, 0.1 mg/kg, 0.3 mg/kg
Administration:Oral administration; once
Result:Inhibited hyperlocomotion induced by Phencyclidine.
体外研究：
ASP2905 potently inhibits potassium currents in CHO cells expressing KCNH3 (IC50 of 9.0 nM). ASP2905 (≤10 μM) minimally bound with low affinities to 55 transmembrane proteins. ASP2905 (0.1 μM, 1 μM) decreases the frequency of spontaneous inhibitory postsynaptic currents in cultured rat hippocampal neurons.
ASP2905 is a potent and selective potassium channel Kv12.2 inhibitor encoded by the Kcnh3/BEC1 gene. ASP2905 can cross the blood-brain barrier and has antipsychotic activities.
体内研究：
ASP2905 treatment inhibits hyperlocomotion induced by Phencyclidine. And significantly ameliorates Phencyclidine-induced prolongation of immobility time in mice subjected to the forced swimming test.Animal Model:Male ddY mice (aged 4-5 weeks) injected with Phencyclidine hydrochloride (PCP)
Dosage:0.01 mg/kg, 0.03 mg/kg, 0.1 mg/kg, 0.3 mg/kg
Administration:Oral administration; once
Result:Inhibited hyperlocomotion induced by Phencyclidine.
体外研究：
ASP2905 potently inhibits potassium currents in CHO cells expressing KCNH3 (IC50 of 9.0 nM). ASP2905 (≤10 μM) minimally bound with low affinities to 55 transmembrane proteins. ASP2905 (0.1 μM, 1 μM) decreases the frequency of spontaneous inhibitory postsynaptic currents in cultured rat hippocampal neurons.
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