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编 号:F460615
分子式:C75H112O36
分子量:1589.67
产品类型
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CAS No: 79103-90-5
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生物活性:
Polygalasaponin XXXI (Onjisaponin F) is an effective adjuvant for intranasal administration of influenza Influenza hemagglutinin (HA) vaccine to protect influenza virus infection.
体内研究:
Intranasal vaccination with Polygalasaponin XXXI (Onjisaponin F) inhibits proliferation of mouse adapted influenza virus A/PR/8/34 in bronchoalveolar lavages of infected mice.
体外研究:
Polygalasaponin XXXI (Onjisaponin F) also enhances anti-HA IgA and IgG Ab titers in the nasal wash, whereas Onjisaponins E and G enhances only anti-HA IgA Ab titer significantly. Polygalasaponin XXXI can induce protective immunity against intranasal infection by influenza virus.Polygalasaponin XXXI (Onjisaponin F) (1 or 10 μg/mL) also induces ChAT mRNA level in rat basal forebrain cells.