产品
编 号：F456150
分子式：C30H48O3
分子量：456.7
分子式：C30H48O3
分子量：456.7
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
100
In-stock
5mg
175
In-stock
10mg
280
In-stock
50mg
400
In-stock
100mg
520
In-stock
200mg
780
In-stock
结构图
CAS No: 77-52-1
产品详情
生物活性：
Ursolic acid (Prunol) is a natural pentacyclic triterpenoid carboxylic acid, exerts anti-tumor effects and is an effective compound for cancer prevention and therapy.
体内研究：
Ursolic acid treatment markedly improves the survival of septic rats, and attenuated CLP-induced lung injury, including reduction of lung wet/dry weight ratio, infiltration of leukocytes and proteins, myeloperoxidase activity, and malondialdehyde content. In addition, Ursolic acid significantly decreases the serum levels of tumor necrosis factor-α, interleukin-6, and interleukin-1β, inhibits the expression of inducible nitric oxide synthase and cyclooxygenase-2 in the lung, which are involved in the productions of nitric oxide and prostaglandin E2.
体外研究：
Ursolic acid induces phosphorylation of AMP-activated protein kinase alpha (AMPKα) and suppressed the protein expression of DNA methyltransferase 1 (DNMT1) in the dose-dependent manner. The combination of Ursolic acid (0.5 μM) and Leucine (10 μM) prove to be the most effective in promoting myogenic differentiation. The combination of Ursolic acid and Leucine significantly increase CK activity than treatment with either agent alone. The level of myosin heavy chain, a myogenic differentiation marker protein, is also enhanced by the combination of Ursolic acid and Leucine. Ursolic acid efficiently induces apoptosis, possibly via the downregulation of B-cell lymphoma 2 (Bcl-2), the upregulation of Bcl-2-associated X protein and the proteolytic activation of caspase-3. Furthermore, the activation of p38 mitogen-activated protein kinase and c-Jun N-terminal kinase is increased by the administration of ursolic acid. In addition, Ursolic acid significantly suppresses the invasive phenotype of the SNU-484 cells and significantly decreases the expression of matrix metalloproteinase (MMP)-2. Ursolic acid (UA) potently induces the apoptosis of gastric cancer SGC-7901 cells. Further mechanistic studies revealed that the ROCK1/PTEN signaling pathway plays a critical role in Ursolic acid-mediated mitochondrial translocation of cofilin-1 and apoptosis.
Ursolic acid (Prunol) is a natural pentacyclic triterpenoid carboxylic acid, exerts anti-tumor effects and is an effective compound for cancer prevention and therapy.
体内研究：
Ursolic acid treatment markedly improves the survival of septic rats, and attenuated CLP-induced lung injury, including reduction of lung wet/dry weight ratio, infiltration of leukocytes and proteins, myeloperoxidase activity, and malondialdehyde content. In addition, Ursolic acid significantly decreases the serum levels of tumor necrosis factor-α, interleukin-6, and interleukin-1β, inhibits the expression of inducible nitric oxide synthase and cyclooxygenase-2 in the lung, which are involved in the productions of nitric oxide and prostaglandin E2.
体外研究：
Ursolic acid induces phosphorylation of AMP-activated protein kinase alpha (AMPKα) and suppressed the protein expression of DNA methyltransferase 1 (DNMT1) in the dose-dependent manner. The combination of Ursolic acid (0.5 μM) and Leucine (10 μM) prove to be the most effective in promoting myogenic differentiation. The combination of Ursolic acid and Leucine significantly increase CK activity than treatment with either agent alone. The level of myosin heavy chain, a myogenic differentiation marker protein, is also enhanced by the combination of Ursolic acid and Leucine. Ursolic acid efficiently induces apoptosis, possibly via the downregulation of B-cell lymphoma 2 (Bcl-2), the upregulation of Bcl-2-associated X protein and the proteolytic activation of caspase-3. Furthermore, the activation of p38 mitogen-activated protein kinase and c-Jun N-terminal kinase is increased by the administration of ursolic acid. In addition, Ursolic acid significantly suppresses the invasive phenotype of the SNU-484 cells and significantly decreases the expression of matrix metalloproteinase (MMP)-2. Ursolic acid (UA) potently induces the apoptosis of gastric cancer SGC-7901 cells. Further mechanistic studies revealed that the ROCK1/PTEN signaling pathway plays a critical role in Ursolic acid-mediated mitochondrial translocation of cofilin-1 and apoptosis.
产品资料
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