产品
编 号：F455823
分子式：C19H14N4O4
分子量：362.34
分子式：C19H14N4O4
分子量：362.34
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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1mg
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5mg
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10mg
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25mg
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50mg
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结构图
CAS No: 77422-99-2
产品详情
生物活性：
PD 90780 is a non peptide antagonist of nerve growth factor (NGF). PD 90780 interacts with NGF, prevents NGF binds with p75NTR. PD 90780 inhibits NGF-p75NTR interaction with IC50s of 23.1 and 1.8 μM in PC12 cells and PC12nnr5 cells, respectively .
体外研究：
PD 90780 (0.1-100 μM; 2 h) affects 125I-BDNF binds to truncated p75NTR.PD 90780 (100 μM; 2 h) inhibits 125I-NGF cross-linking to p75NTR.PD 90780 (0-300 μM; 2 h) decreases TrkA phosphorylation resulting from NGF binding with a dose of 300 μM.PD 90780 (0.1-100 μM; 2 h) inhibits NGF-p75NTR interaction with IC50 values of 23.1 μM and 1.8 μM in PC12 cells and PC12nnr5 cells, respectively.
PD 90780 is a non peptide antagonist of nerve growth factor (NGF). PD 90780 interacts with NGF, prevents NGF binds with p75NTR. PD 90780 inhibits NGF-p75NTR interaction with IC50s of 23.1 and 1.8 μM in PC12 cells and PC12nnr5 cells, respectively .
体外研究：
PD 90780 (0.1-100 μM; 2 h) affects 125I-BDNF binds to truncated p75NTR.PD 90780 (100 μM; 2 h) inhibits 125I-NGF cross-linking to p75NTR.PD 90780 (0-300 μM; 2 h) decreases TrkA phosphorylation resulting from NGF binding with a dose of 300 μM.PD 90780 (0.1-100 μM; 2 h) inhibits NGF-p75NTR interaction with IC50 values of 23.1 μM and 1.8 μM in PC12 cells and PC12nnr5 cells, respectively.
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