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编 号：F455404
分子式：C24H33FO7
分子量：443.51
分子式：C24H33FO7
分子量：443.51
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CAS No: 77326-96-6
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生物活性：
Flunisolide hemihydrate is a corticosteroid, which is an orally active glucocorticoid receptor activator with anti-inflammatory activity. Flunisolide hemihydrate can induce eosinophil apoptosis, and is used for the research of asthma or rhinitis, and inflammation.
体内研究：
Flunisolide hemihydrate (Intranasal administration, 0.3-10 μg/mouse, daily, from days 21–27) inhibits lung inflammation, fibrosis, and airway hyper-reactivity, also improves clearance of silica particles from the lungs in silicotic mice.Flunisolide hemihydrate (Intranasal administration, 0.3-10 μg/mouse, daily, from days 21–27) inhibits silica-induced macrophage and myofibroblast accumulation in the lung tissue.Animal Model:Male Swiss Webster mice (instilled, intranasally, with crystalline silica, 10 mg/50 μL, particle size 0.5-10 μm)
Dosage:0.3-10 μg/mouse, daily, from days 21-27
Administration:Intranasal administration
Result:Reduced both granulomatous response, collagen deposition, concerning granuloma formation caused by silica particles.Reduced the number of F4/80 and α-SMA positive cells.
体外研究：
Flunisolide hemihydrate (0.1-10 μM, 1 h) inhibits lung fibroblast (Isolated from lung) activation.Flunisolide hemihydrate (10 μM, 24 h) reduces MMP-9, TIMP-1, TGF-β and fibronectin release by sputum cells (isolated frommild to moderate asthmatics), and induces sputum eosinophil apoptosis.Flunisolide hemihydrate (0.1-10 μM μM, 24 h) effectively inhibits ICAM-1 expression and GM-CSF and IL-5 release induced by TNF-alpha in BEAS-2B cells.Flunisolide hemihydrate (115 μM, 0-3 h) can be transported in a polarized way in the apical (ap) to basolateral (bl) direction in Calu-3 cells and is demonstrated to be ATP-dependent.
Flunisolide hemihydrate is a corticosteroid, which is an orally active glucocorticoid receptor activator with anti-inflammatory activity. Flunisolide hemihydrate can induce eosinophil apoptosis, and is used for the research of asthma or rhinitis, and inflammation.
体内研究：
Flunisolide hemihydrate (Intranasal administration, 0.3-10 μg/mouse, daily, from days 21–27) inhibits lung inflammation, fibrosis, and airway hyper-reactivity, also improves clearance of silica particles from the lungs in silicotic mice.Flunisolide hemihydrate (Intranasal administration, 0.3-10 μg/mouse, daily, from days 21–27) inhibits silica-induced macrophage and myofibroblast accumulation in the lung tissue.Animal Model:Male Swiss Webster mice (instilled, intranasally, with crystalline silica, 10 mg/50 μL, particle size 0.5-10 μm)
Dosage:0.3-10 μg/mouse, daily, from days 21-27
Administration:Intranasal administration
Result:Reduced both granulomatous response, collagen deposition, concerning granuloma formation caused by silica particles.Reduced the number of F4/80 and α-SMA positive cells.
体外研究：
Flunisolide hemihydrate (0.1-10 μM, 1 h) inhibits lung fibroblast (Isolated from lung) activation.Flunisolide hemihydrate (10 μM, 24 h) reduces MMP-9, TIMP-1, TGF-β and fibronectin release by sputum cells (isolated frommild to moderate asthmatics), and induces sputum eosinophil apoptosis.Flunisolide hemihydrate (0.1-10 μM μM, 24 h) effectively inhibits ICAM-1 expression and GM-CSF and IL-5 release induced by TNF-alpha in BEAS-2B cells.Flunisolide hemihydrate (115 μM, 0-3 h) can be transported in a polarized way in the apical (ap) to basolateral (bl) direction in Calu-3 cells and is demonstrated to be ATP-dependent.
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