产品
编 号：F455180
分子式：C21H37ClN4O8S
分子量：541.06
分子式：C21H37ClN4O8S
分子量：541.06
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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5mg
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10mg
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25mg
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50mg
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100mg
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结构图
CAS No: 773092-05-0
产品详情
生物活性：
Acotiamide monohydrochloride trihydrate is an orally active, selective and reversible acetylcholinesterase (AChE) inhibitor, with IC50 of 1.79 μM. Acotiamide monohydrochloride trihydrate can enhance gastric contractility and accelerate delayed gastric emptying. Acotiamide monohydrochloride trihydrate has the potential for the research of functional dyspepsia involving gastric motility dysfunction and intestinal inflammatory .
体内研究：
Acotiamide monohydrochloride trihydrate (0.3, 1, 3 mg/kg; i.v./3, 10, 30 mg/kg; p.o.) increases the postprandial gastric motility index in a dose-dependent manner.Acotiamide monohydrochloride trihydrate (0.83 mg/kg; i.v.; once) inhibits AChE in rat stomach with IC50 of 1.79 μM.Animal Model:Male mongrel dogs (9-11 kg), Male beagle dogs (9.6-12.9 kg)
Dosage:0.3, 1, 3, 10, 30 mg/kg
Administration:Intravenous injection; once.
Result:Increased the postprandial gastric motility.
Animal Model:Male Sprague-Dawley rats (aged 6-7 weeks)
Dosage:0.83 mg/kg
Administration:Intravenous injection; once.
Result:Effectively improved functional dyspepsia by inhibiting AChE in rat stomach.
体外研究：
Acotiamide monohydrochloride trihydrate (10, 30, 100 μM; 1 hour) reduces expression levels of IκB-α phosphorylation in LPS- and MCP-1-stimulated macrophage cell lines.
Acotiamide monohydrochloride trihydrate is an orally active, selective and reversible acetylcholinesterase (AChE) inhibitor, with IC50 of 1.79 μM. Acotiamide monohydrochloride trihydrate can enhance gastric contractility and accelerate delayed gastric emptying. Acotiamide monohydrochloride trihydrate has the potential for the research of functional dyspepsia involving gastric motility dysfunction and intestinal inflammatory .
体内研究：
Acotiamide monohydrochloride trihydrate (0.3, 1, 3 mg/kg; i.v./3, 10, 30 mg/kg; p.o.) increases the postprandial gastric motility index in a dose-dependent manner.Acotiamide monohydrochloride trihydrate (0.83 mg/kg; i.v.; once) inhibits AChE in rat stomach with IC50 of 1.79 μM.Animal Model:Male mongrel dogs (9-11 kg), Male beagle dogs (9.6-12.9 kg)
Dosage:0.3, 1, 3, 10, 30 mg/kg
Administration:Intravenous injection; once.
Result:Increased the postprandial gastric motility.
Animal Model:Male Sprague-Dawley rats (aged 6-7 weeks)
Dosage:0.83 mg/kg
Administration:Intravenous injection; once.
Result:Effectively improved functional dyspepsia by inhibiting AChE in rat stomach.
体外研究：
Acotiamide monohydrochloride trihydrate (10, 30, 100 μM; 1 hour) reduces expression levels of IκB-α phosphorylation in LPS- and MCP-1-stimulated macrophage cell lines.
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