产品
编 号：F454959
分子式：C20H31NO3
分子量：333.47
分子式：C20H31NO3
分子量：333.47
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规格
价格
是否有货
10mM*1mL in DMSO
询价
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5mg
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10mg
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25mg
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50mg
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100mg
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结构图
CAS No: 77-23-6
产品详情
生物活性：
Pentoxyverine (Carbetapentane) is an orally active sigma-1 receptor agonist, with Kis of 41 nM, 894 nM and 75 nM for σ1, σ2 and guinea-pig brain membran σ1, respectively. Pentoxyverine is a muscarinic antagonist. Pentoxyverine is a potent antitussive, anticonvulsant, and spasmolytic agent. Pentoxyverine can be used for inhibiting bronchial interceptor, weakening of cough reflex, bronchial smooth muscle relaxation and reduction of airway resistance.
体内研究：
Pentoxyverine (Carbetapentane；1-32mg/kg；皮下给药) 在小鼠的爪子注射辣椒素 (HY-10448) 进行刺激下，可以剂量依赖性地增强辣椒素对机械刺激的敏化作用。 Pentoxyverine (16?mg/kg；皮下给药) 对辣椒素引起的继发性机械异常性疼痛有很强的增强作用。 Pentoxyverine (50?mg/kg；口服) 可以用作阳性对照，对任一性别的小鼠 (22-25?g) 给药7天后，使氨水诱导的咳嗽潜伏期百分比增加121.72％，抑制咳嗽频率45.45％。 Animal Model:Female wild-type weighing 25 to 30?g
Dosage:0.5, 1, 2, 4, 8, 16, 32 mg/kg
Administration:SC; 30?min before the intraplantar (i.pl.) administration of capsaicin (0.125?μg)
Result:Dose-dependently potentiated the sensitizing effect of capsaicin to the mechanical stimulus when the mice were stimulated in the paw injected with capsaicin.
Pentoxyverine (Carbetapentane) is an orally active sigma-1 receptor agonist, with Kis of 41 nM, 894 nM and 75 nM for σ1, σ2 and guinea-pig brain membran σ1, respectively. Pentoxyverine is a muscarinic antagonist. Pentoxyverine is a potent antitussive, anticonvulsant, and spasmolytic agent. Pentoxyverine can be used for inhibiting bronchial interceptor, weakening of cough reflex, bronchial smooth muscle relaxation and reduction of airway resistance.
体内研究：
Pentoxyverine (Carbetapentane；1-32mg/kg；皮下给药) 在小鼠的爪子注射辣椒素 (HY-10448) 进行刺激下，可以剂量依赖性地增强辣椒素对机械刺激的敏化作用。 Pentoxyverine (16?mg/kg；皮下给药) 对辣椒素引起的继发性机械异常性疼痛有很强的增强作用。 Pentoxyverine (50?mg/kg；口服) 可以用作阳性对照，对任一性别的小鼠 (22-25?g) 给药7天后，使氨水诱导的咳嗽潜伏期百分比增加121.72％，抑制咳嗽频率45.45％。 Animal Model:Female wild-type weighing 25 to 30?g
Dosage:0.5, 1, 2, 4, 8, 16, 32 mg/kg
Administration:SC; 30?min before the intraplantar (i.pl.) administration of capsaicin (0.125?μg)
Result:Dose-dependently potentiated the sensitizing effect of capsaicin to the mechanical stimulus when the mice were stimulated in the paw injected with capsaicin.
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