产品
编 号：F453656
分子式：C6H8N4O4
分子量：200.15
分子式：C6H8N4O4
分子量：200.15
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
500mg
询价
询价
1g
询价
询价
结构图
CAS No: 7681-76-7
产品详情
生物活性：
Ronidazole is a potent and orally active antiprotozoal and anti-microbial agent. Ronidazole acts as a veterinary agent against Tritrichomonas foetus?in cats models. Ronidazole can be used the research of forhistomoniasis?and?swine?dysentery.
体内研究：
药代动力学分析Drug administrationDose (mg/kg)T1/2 (K) (h)C0 (μg/mL)AUC 0-∞ (h?μg/m)Vd or Vd/F (mL/kg)Clearance or CL/F (h)MRT (h)Tmax (h)Cmax (μg/m)F (%)
Dose (mg/kg) Time (h) AUClast Cmax (ng/mL) i.v.9.1759.8013.27187.307000.8214.14NANANA
p.o.28.2310.50NA566.987700.84NA1.0235.3799.64
In Vitro:Ronidazole potently inhibited the growth of all 24 clinical isolates of C. difficile tested.Ronidazole (0.3125 μg/mL, 1.25 μg/mL; 8 hours) can reduce the C. difficile bacteria count to below the detection limit, and has concentration-dependent bactericidal activity against C. difficile bacteria.Animal Model:
Dosage:
Administration:
Result:
Animal Model:CDI mice model
Dosage:1 mg/kg, 10mg/kg
Administration:Oral gavage
Result:Both 1 mg/kg and 10 mg/kg Ronidazole protected 60% of mice from infection
体外研究：
Ronidazole (0.0625~0.25 μg/mL;48 hours) 能有效抑制 24 株 C. difficile 细菌的生长.Ronidazole (0.3125 μg/mL, 1.25 μg/mL; 8 hours) 能将 C. difficile 细菌的数量降低至检出限以下，且对 C. difficile 细菌具有浓度依赖性的杀菌活性.
Ronidazole is a potent and orally active antiprotozoal and anti-microbial agent. Ronidazole acts as a veterinary agent against Tritrichomonas foetus?in cats models. Ronidazole can be used the research of forhistomoniasis?and?swine?dysentery.
体内研究：
药代动力学分析Drug administrationDose (mg/kg)T1/2 (K) (h)C0 (μg/mL)AUC 0-∞ (h?μg/m)Vd or Vd/F (mL/kg)Clearance or CL/F (h)MRT (h)Tmax (h)Cmax (μg/m)F (%)
Dose (mg/kg) Time (h) AUClast Cmax (ng/mL) i.v.9.1759.8013.27187.307000.8214.14NANANA
p.o.28.2310.50NA566.987700.84NA1.0235.3799.64
In Vitro:Ronidazole potently inhibited the growth of all 24 clinical isolates of C. difficile tested.Ronidazole (0.3125 μg/mL, 1.25 μg/mL; 8 hours) can reduce the C. difficile bacteria count to below the detection limit, and has concentration-dependent bactericidal activity against C. difficile bacteria.Animal Model:
Dosage:
Administration:
Result:
Animal Model:CDI mice model
Dosage:1 mg/kg, 10mg/kg
Administration:Oral gavage
Result:Both 1 mg/kg and 10 mg/kg Ronidazole protected 60% of mice from infection
体外研究：
Ronidazole (0.0625~0.25 μg/mL;48 hours) 能有效抑制 24 株 C. difficile 细菌的生长.Ronidazole (0.3125 μg/mL, 1.25 μg/mL; 8 hours) 能将 C. difficile 细菌的数量降低至检出限以下，且对 C. difficile 细菌具有浓度依赖性的杀菌活性.
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