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编 号：F453385
分子式：C66H86N18O12
分子量：1323.5
分子式：C66H86N18O12
分子量：1323.5
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CAS No: 76712-82-8
产品详情
生物活性：
Histrelin, a GnRH analogue, is a GnRH Receptor agonist. Histrelin increases serum luteinising hormone (LH), follicle stimulating hormone (FSH) and testosterone levels. Histrelin can be used in the research of prostate cancer, endometriosis.
体内研究：
Histrelin (0.1 mg/kg，皮下注射) 可恢复 Csfmop/Csfmop 小鼠中的循环 LH 浓度。Histrelin （10,30 或 100 μg/天，皮下注射)会减少兔子的子宫内膜腺体数量并使间质萎缩。Animal Model:Csfmop/Csfmop mice
Dosage:0.001, 0.05, and 0.1 mg/kg
Administration:Subcutaneous injection
Result:Increased serum FSH concentrations by 4-fold.
Animal Model:Rabbits
Dosage:10, 30, or 100 μg /day
Administration:Subcutaneous injection for 4 weeks
Result:Caused a regression of the endometrial glands and a thinning of the stroma.
体外研究：
Histrelin (10-100 nM) stimulates the release of vasopressin (VP) from from isolated rat hypothalamo-neurohypophysial explants.Histrelin (100 nM) stimulates oxytocin (OT) release from the rat hypothalamo-neurohypophysial system.
Histrelin, a GnRH analogue, is a GnRH Receptor agonist. Histrelin increases serum luteinising hormone (LH), follicle stimulating hormone (FSH) and testosterone levels. Histrelin can be used in the research of prostate cancer, endometriosis.
体内研究：
Histrelin (0.1 mg/kg，皮下注射) 可恢复 Csfmop/Csfmop 小鼠中的循环 LH 浓度。Histrelin （10,30 或 100 μg/天，皮下注射)会减少兔子的子宫内膜腺体数量并使间质萎缩。Animal Model:Csfmop/Csfmop mice
Dosage:0.001, 0.05, and 0.1 mg/kg
Administration:Subcutaneous injection
Result:Increased serum FSH concentrations by 4-fold.
Animal Model:Rabbits
Dosage:10, 30, or 100 μg /day
Administration:Subcutaneous injection for 4 weeks
Result:Caused a regression of the endometrial glands and a thinning of the stroma.
体外研究：
Histrelin (10-100 nM) stimulates the release of vasopressin (VP) from from isolated rat hypothalamo-neurohypophysial explants.Histrelin (100 nM) stimulates oxytocin (OT) release from the rat hypothalamo-neurohypophysial system.
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