产品
编 号：F452316
分子式：C5H12NO5P
分子量：197.13
分子式：C5H12NO5P
分子量：197.13
产品类型
规格
价格
是否有货
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
50mg
询价
询价
结构图
CAS No: 76326-31-3
产品详情
生物活性：
DL-AP5 (2-APV) is a competitive NMDA (N-methyl-D-aspartate) receptor antagonist. DL-AP5 shows significantly antinociceptive activity. DL-AP5 specifically blocks on channels in the rabbit retina.
体内研究：
DL-AP5 (0-10 μg/rat, Intra-CA1) significantly decreases the effect of NMDA.DL-AP5 (0-10 nmol, Intracerebroventricular injection) causes a dose-dependent increase in food consumption.DL-AP5 (5 nmol, Intracerebroventricular injection) attenuates the decreased food consumption induced by the intracerebroventricular injection of ghrelin.Animal Model:Male Wistar rats (180-230 g)
Dosage:1, 3.2 and 10 μg/rat
Administration:Injected into the intra-dorsal hippocampal (intra-CA1) immediately after shock administration, once
Result:Significantly decreased the effect of NMDA (10-2 μg/rat, intra-CA1) with significant interaction.
Animal Model:Broilers cockerels (3-h fooddeprived (FD3), n=8 for each group)
Dosage:0, 2.5, 5, and 10 nmol; in a volume of 10 μL
Administration:Intracerebroventricular injection
Result:Caused a dose-dependent increase in food consumption which was significant for 5 and 10 nmol doses.
Animal Model:Broilers cockerels (3-h fooddeprived (FD3), n=8 for each group)
Dosage:5 nmol
Administration:Intracerebroventricular injection, followed by ghrelin (0.6 nmol)
Result:Attenuated the decreased food consumption induced by the intracerebroventricular injection of ghrelin.
体外研究：
DL-AP5 (100 μM) partially prevents glutamate-induced increase in Arc/Arg3.1 protein levels.DL-AP5 decreases the NMDA-induced Arc/Arg3.1 upregulation.
DL-AP5 (2-APV) is a competitive NMDA (N-methyl-D-aspartate) receptor antagonist. DL-AP5 shows significantly antinociceptive activity. DL-AP5 specifically blocks on channels in the rabbit retina.
体内研究：
DL-AP5 (0-10 μg/rat, Intra-CA1) significantly decreases the effect of NMDA.DL-AP5 (0-10 nmol, Intracerebroventricular injection) causes a dose-dependent increase in food consumption.DL-AP5 (5 nmol, Intracerebroventricular injection) attenuates the decreased food consumption induced by the intracerebroventricular injection of ghrelin.Animal Model:Male Wistar rats (180-230 g)
Dosage:1, 3.2 and 10 μg/rat
Administration:Injected into the intra-dorsal hippocampal (intra-CA1) immediately after shock administration, once
Result:Significantly decreased the effect of NMDA (10-2 μg/rat, intra-CA1) with significant interaction.
Animal Model:Broilers cockerels (3-h fooddeprived (FD3), n=8 for each group)
Dosage:0, 2.5, 5, and 10 nmol; in a volume of 10 μL
Administration:Intracerebroventricular injection
Result:Caused a dose-dependent increase in food consumption which was significant for 5 and 10 nmol doses.
Animal Model:Broilers cockerels (3-h fooddeprived (FD3), n=8 for each group)
Dosage:5 nmol
Administration:Intracerebroventricular injection, followed by ghrelin (0.6 nmol)
Result:Attenuated the decreased food consumption induced by the intracerebroventricular injection of ghrelin.
体外研究：
DL-AP5 (100 μM) partially prevents glutamate-induced increase in Arc/Arg3.1 protein levels.DL-AP5 decreases the NMDA-induced Arc/Arg3.1 upregulation.
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