产品
编 号：F451600
分子式：C17H15N3O
分子量：277.32
分子式：C17H15N3O
分子量：277.32
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
50mg
询价
询价
结构图
CAS No: 76081-98-6
产品详情
生物活性：
SCH28080 is a reversible, K+-competitive inhibitor of the gastric H,K-ATPase, with a Ki of 0.12 μM. SCH28080 is an effective inhibitor of acid secretion in vivo and with anti-gastric ulcer activity.
体内研究：
SCH28080 (20 mg/kg; i.p.) inhibits gastric ulcers induced by pylorusligation in rats.Animal Model:Male Wistar rat (280-350 g), the Shay rat model
Dosage:20 mg/kg
Administration:Intraperitoneal injection
Result:Showed 91% inhibition on gastric ulcers induced by pylorusligation in rats.
体外研究：
SCH28080 competitively inhibits the K+-stimulated hydrolysis of ATP, with a Ki of 0.12 μM .SCH28080 inhibits histamine-induced [14C]aminopyrine uptake into isolated rabbit parietalcells with an IC50 of 0.029 μM.SCH28080 causes a dose-dependent reduction in cell viability with IC50 values of 22.9 μM and 15.3 μM after 2 h and 24 h treatments, respectively, and cell viability was below 10% at 100 μM already after 2 h treatment.SCH28080 induces apoptosis and is cytotoxic at higher doses.SCH28080 inhibits insulin secretion by activation of IK ATP and inhibition of L-type voltage-gated Ca2+ channels, reduces cell viability and dose-dependently induces apoptosis/necrosis.
SCH28080 is a reversible, K+-competitive inhibitor of the gastric H,K-ATPase, with a Ki of 0.12 μM. SCH28080 is an effective inhibitor of acid secretion in vivo and with anti-gastric ulcer activity.
体内研究：
SCH28080 (20 mg/kg; i.p.) inhibits gastric ulcers induced by pylorusligation in rats.Animal Model:Male Wistar rat (280-350 g), the Shay rat model
Dosage:20 mg/kg
Administration:Intraperitoneal injection
Result:Showed 91% inhibition on gastric ulcers induced by pylorusligation in rats.
体外研究：
SCH28080 competitively inhibits the K+-stimulated hydrolysis of ATP, with a Ki of 0.12 μM .SCH28080 inhibits histamine-induced [14C]aminopyrine uptake into isolated rabbit parietalcells with an IC50 of 0.029 μM.SCH28080 causes a dose-dependent reduction in cell viability with IC50 values of 22.9 μM and 15.3 μM after 2 h and 24 h treatments, respectively, and cell viability was below 10% at 100 μM already after 2 h treatment.SCH28080 induces apoptosis and is cytotoxic at higher doses.SCH28080 inhibits insulin secretion by activation of IK ATP and inhibition of L-type voltage-gated Ca2+ channels, reduces cell viability and dose-dependently induces apoptosis/necrosis.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备