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编 号:F451556
分子式:C17H22O4
分子量:290.35
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生物活性:
6-Dehydrogingerdione sensitizes human hepatoblastoma Hep G2 cells to TRAIL-induced apoptosis via reactive oxygen species-mediated increase of DR5.

体外研究:
6-Dehydrogingerdione could trigger apoptotic cell death via both mitochondrial- and Fas receptor-mediated pathways.6-Dehydrogingerdione (6-DG) up-regulates Ser-15 phosphorylation and evoked p53 nuclear translocation.6-Dehydrogingerdione (6-DG) induces mitochondrial apoptotic pathway.
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