产品
编 号：F451192
分子式：C78H111N21O19
分子量：1646.85
分子式：C78H111N21O19
分子量：1646.85
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 75921-69-6
产品详情
生物活性：
Melanotan I is a potent non-selective melanocortin receptor (MCR) agonist. Melanotan I is a synthetic analogue of α-melanocyte stimulating hormone (α-MSH) that stimulates melanogenesis. Melanotan I can induce skin tanning by mimicking the actions of a-MSH on the melanocortin type 1 receptors (MC1R) of melanocytes. Melanotan I can be used for the research of sun-induced skin cancer, melanoma, inflammation and male erectile dysfunction.
体内研究：
Melanotan I (2 mg/kg/dayfor 12 weeks, s.c.) 在啮齿类动物体内实验中无急性毒性作用。Melanotan I (2/10 mg/kg, s.c.) 不会增加 SCID (免疫缺陷) 小鼠中人类黑色素瘤的肿瘤发生率，也不会导致肿瘤恶性转化，没有表现出促癌作用。Animal Model: rats
Dosage:0.6 mg/kg/day for 30 days
Administration:s.c.
Result:Well tolerated with no change in lethality, no effect on weight gain, no serum chemistry changes, except for a slight increase (30 %) in lactic dehydrogenase levels.
体外研究：
Melanotan I (1 μM, 72 h) 不会改变或轻微抑制肿瘤集落的形成，在体外抑制黑色素瘤细胞增殖。
Melanotan I is a potent non-selective melanocortin receptor (MCR) agonist. Melanotan I is a synthetic analogue of α-melanocyte stimulating hormone (α-MSH) that stimulates melanogenesis. Melanotan I can induce skin tanning by mimicking the actions of a-MSH on the melanocortin type 1 receptors (MC1R) of melanocytes. Melanotan I can be used for the research of sun-induced skin cancer, melanoma, inflammation and male erectile dysfunction.
体内研究：
Melanotan I (2 mg/kg/dayfor 12 weeks, s.c.) 在啮齿类动物体内实验中无急性毒性作用。Melanotan I (2/10 mg/kg, s.c.) 不会增加 SCID (免疫缺陷) 小鼠中人类黑色素瘤的肿瘤发生率，也不会导致肿瘤恶性转化，没有表现出促癌作用。Animal Model: rats
Dosage:0.6 mg/kg/day for 30 days
Administration:s.c.
Result:Well tolerated with no change in lethality, no effect on weight gain, no serum chemistry changes, except for a slight increase (30 %) in lactic dehydrogenase levels.
体外研究：
Melanotan I (1 μM, 72 h) 不会改变或轻微抑制肿瘤集落的形成，在体外抑制黑色素瘤细胞增殖。
产品资料
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