产品
编 号:F451013
分子式:C21H29Cl2N3
分子量:394.38
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1mg
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5mg
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10mg
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25mg
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50mg
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100mg
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生物活性:
Rimcazole (BW 234U) dihydrochloride is a carbazole derivative that acts in part as a sigma (σ) receptor antagonist. Rimcazole dihydrochloride also binds with moderate affinity to the dopamine transporter and inhibit dopamine uptake. Rimcazole dihydrochloride can reduce locomotor activity and sensitization. Rimcazole dihydrochloride also can be used for the research of cancer.

体外研究:
Rimcazole (1-50 μM;24-48 小时)浓度依赖性地降低 HCT-116p53+/+ 细胞的数量。Rimcazole (50 μM;1-24 小时) 在癌细胞 (HCT-116p53+/+ 和 MDA-MB-231 细胞) 中诱导 HIF-1α 蛋白的瞬时积累,但在正常人真皮成纤维细胞中没有这种现象。
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